Developmental changes of apolipoprotein E immunoreactivity in Down syndrome brains
Abstract
The temporal profile of apolipoprotein-E (apo-E) expression was investigated immunohistochemically in the brains of Down syndrome patients and of normal controls. The number of apo-E immunoreactive astrocytes in the frontal cortex was larger in Down syndrome patients than in controls from 7 months to 24 years of age. It suggests that apo-E producing astrocytes in the early phase of pathological process lead to presenile dementia in Down syndrome patients. In contrast, the number in the white matter was smaller in Down syndrome patients from 28 gestational weeks to 5 years. Apo-E immunoreactive senile plaques were noted in Down syndrome brains from the age of 25 years, while APP immunoreactivity was first noted in senile plaques at the age of 32 years.
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APOE is sequestered in amyloid-β plaques within the brain, including in individuals with DSAD.
“Previous studies have shown that APOE is sequestered in amyloid-β plaques within the brain, including in individuals with DSAD [3, 13], similar to what we have observed (Supplementary Fig. 9).”
From Apolipoprotein E abundance is elevated in the brains of individuals with Down syndrome–Alzheimer’s disease (2025) · cites this paper as [3]
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Farrell, C., Buhidma, Y., Mumford, P., Heywood, W. E., Hällqvist, J., Flores-Aguilar, L., Andrews, E. J., Rahimzadah, N., Taso, O. S., Doran, E., et al. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02889-0 · Cited by 9 · see citing works
“Previous studies have shown that APOE is sequestered in amyloid-β plaques within the brain, including in individuals with DSAD [3, 13], similar to what we have observed (Supplementary Fig.”
- Authors
- Arai, Y., Mizuguchi, M., Ikeda, K., & Takashima, S.
- Affiliations
- National Center of Neurology and Psychiatry (JP)
- Tokyo Institute of Psychiatry (JP)
- ORCID
- Mizuguchi, Masashi
- Venue
- Developmental Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 87
- Issue
- 2
- Pages
- 228-232
- ISSN
- 0165-3806 (ISSN-L)
- OpenAlex
- W1997879125
- Cited by
- 15
- References
- 0
- Citations by year
- 2025: 2 · 2022: 3 · 2020: 1 · 2019: 1 · 2018: 1
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Developmental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- apolipoprotein E, Down syndrome, astrocytes, frontal cortex, white matter, amyloid plaques, amyloid precursor protein, early-onset dementia, brain development, immunoreactivity
- MeSH terms
- Adolescent, Adult, Aging, Apolipoproteins E, Astrocytes, Brain, Child, Child, Preschool, Down Syndrome, Embryonic and Fetal Development, Fetus, Humans, Immunohistochemistry, Infant, Infant, Newborn, Middle Aged, Tissue Distribution
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