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Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice
Open accessAbstract
Experimental allergic encephalomyelitis (EAE) was induced in Biozzi AB/H (antibody high) mice by sensitization with spinal cord homogenate in adjuvant. Biozzi AB/H mice were highly susceptible to EAE induction and followed a chronic relapsing pattern of disease. Disease episodes were characterized by mononuclear infiltration of the central nervous system, with demyelination being particularly evident in relapse. The cellular infiltrates, which were associated with immunoglobulin deposition, consisted of macrophages and primarily CD4-positive T lymphocytes. However, similarly treated Biozzi AB/L (antibody low) mice were markedly less susceptible to EAE induction than AB/H mice. Thus, Biozzi mice should prove valuable for the study of chronic relapsing EAE.
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Self-citationAnderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., et al. (2008) · Brain · doi:10.1093/brain/awn119 · Cited by 141
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Metadata
- Authors
- Baker, D., O'Neill, J. K., Gschmeissner, S. E., Wilcox, C. E., Butter, C., & Turk, J. L.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1990-08
- Volume
- 28
- Issue
- 3
- Pages
- 261-270
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2079577310
- Cited by
- 192
- References
- 0
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. https://app.cochat.ai/papers/10.1016/0165-5728(90)90019-j
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- Baker, D., O'Neill, J. K., Gschmeissner, S. E., Wilcox, C. E., Butter, C., & Turk, J. L. (1990). Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. Journal of Neuroimmunology. https://doi.org/10.1016/0165-5728(90)90019-j
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.