Insulin and insulin-like growth factors in the CNS

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

Han, V. K. M., D’Ercole, A. J., & Lund, P. K. (1987) · Science · doi:10.1126/science.3563497 · Cited by 657

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

Lund, P. K., Moats‐Staats, B. M., Hynes, M., Simmons, J. G., Jansen, M., D’Ercole, A. J., & Wyk, J. J. V. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66903-0 · Cited by 532

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

Murphy, L. J., Bell, G. I., & Friesen, H. G. (1987) · Endocrinology · doi:10.1210/endo-120-4-1279 · Cited by 418

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413

Blood-brain barrier transcytosis of insulin in developing rabbits

Duffy, K. R., & Pardridge, W. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90236-8 · Cited by 358

Insulin In The Brain

Baskin, D. G., Figlewicz, D. P., Woods, S. C., Porte, D., & Dorsa, D. M. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.002003 · Cited by 344

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

Brown, A. L., Graham, D. E., Nissley, S. P., Hill, D. J., Strain, A. J., & Rechler, M. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69282-8 · Cited by 321

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

Pardridge, W. M. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-3-314 · Cited by 319

ADVANCES IN METABOLIC DISORDERS

Jordan, A. (1965) · Journal of Clinical Pathology · doi:10.1136/jcp.18.5.692-d · Cited by 296

Insulin in the Cerebrospinal Fluid

MARGOLIS, R. U., & ALTSZULER, N. (1967) · Nature · doi:10.1038/2151375a0 · Cited by 278

Insulin-like growth factors and insulin: comparative aspects

Froesch, E. R., & Zapf, J. (1985) · Diabetologia · doi:10.1007/bf00281982 · Cited by 263

Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain.

Clarke, D. W., Boyd, F. T., Kappy, M. S., & Raizada, M. K. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)71260-3 · Cited by 261

Cerebrospinal Fluid Insulin Levels Increase During Intravenous Insulin Infusions in Man*

Wallum, B. J., Taborsky, G. J., Porte, D., Figlewicz, D. P., Jacobson, L., Beard, J. C., Ward, W. K., & Dorsa, D. M. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-1-190 · Cited by 254

Insulin-like growth factor I (IGF I) stimulates DNA synthesis in fetal rat brain cell cultures

Lenoir, D., & Honegger, P. (1983) · Developmental Brain Research · doi:10.1016/0165-3806(83)90177-3 · Cited by 231

Intraventricular insulin reduces food intake and body weight of lean but not obese zucker rats

Ikeda, H., West, D. B., Pustek, J. J., Figlewicz, D. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1986) · Appetite · doi:10.1016/s0195-6663(86)80006-x · Cited by 230

Regional Concentrations of Insulin in the Rat Brain*

Baskin, D. G., Porte, D., GUEST, K., & Dorsa, D. M. (1983) · Endocrinology · doi:10.1210/endo-112-3-898 · Cited by 212

The Type II Insulin-Like Growth Factor (IGF) Receptor Has Low Affinity for IGF-I Analogs: Pleiotypic Actions of IGFs on Myoblasts Are Apparently Mediated by the Type I Receptor*

Dz, E., Falen, S. L., & Florini, J. R. (1987) · Endocrinology · doi:10.1210/endo-120-1-115 · Cited by 208

Characterization of Insulin-Like Growth Factor Receptors in Rat Anterior Pituitary, Hypothalamus, and Brain*

Goodyer, C. G., Stephano, L. D., Lai, W. H., Guyda, H. J., & Posner, B. I. (1984) · Endocrinology · doi:10.1210/endo-114-4-1187 · Cited by 197

Rat insulin-like growth factor II gene

Soares, M. B., Turken, A., Ishii, D. N., Mills, L., Episkopou, V., Cotter, S., Zeitlin, S. O., & Efstratiadis, A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90025-2 · Cited by 194

Ontogenesis of somatomedin and insulin receptors in the human fetus.

Sara, V. R., Hall, K. E., Misaki, M., Fryklund, L., Christensen, N. J., & Wetterberg, L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci110858 · Cited by 194

Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture.

Shemer, J., Raizada, M. K., Masters, B. A., Ota, A., & LeRoith, D. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47623-5 · Cited by 191

The Na,K-ATPase of nervous tissue

Stahl, W. L. (1986) · Neurochemistry International · doi:10.1016/0197-0186(86)90179-8 · Cited by 175

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

Frank, H. J. L., Pardridge, W. M., Morris, W. L., Rosenfeld, R. G., & Choi, T. B. (1986) · Diabetes · doi:10.2337/diab.35.6.654 · Cited by 170

Localization of 125I-insulin binding sites in the rat hypothalamus by quantitative autoradiography

Woods, S. C., Porte, D., Dorsa, D. M., Figlewicz, D. P., & Baskin, D. G. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90430-1 · Cited by 168

Identification of Somatomedin/Insulin-Like Growth Factor Immunoreactive Cells in the Human Fetus

Han, V. K. M., Hill, D. J., Strain, A. J., Towle, A. C., Lauder, J. M., Underwood, L. E., & D’Ercole, A. J. (1987) · Pediatric Research · doi:10.1203/00006450-198709000-00001 · Cited by 164

Evidence for the presence of specific receptors for insulin-like growth factors 1 (IGF-1) and 2 (IGF-2) and insulin throughout the adult human brain

Saka, V. R., Hall, K. E., Holtz, H. V., HUMBEL, R. E., Sjören, B., & Wetterberg, L. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90089-1 · Cited by 164

Two types of receptor for insulin‐like growth factors in mammalian brain.

Gammeltoft, S., Haselbacher, G. K., HUMBEL, R. E., Fehlmann, M., & OBBERGHEN, E. V. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04097.x · Cited by 162

EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

Haselbacher, G. K., & HUMBEL, R. E. (1982) · Endocrinology · doi:10.1210/endo-110-5-1822 · Cited by 160

Periventricular hypothalamic cells in the rat brain contain insulin mRNA

Young, W. S. (1986) · Neuropeptides · doi:10.1016/0143-4179(86)90035-1 · Cited by 148

Genetically obese zucker rats have abnormally low brain insulin content

Baskin, D. G., Stein, L. J., Ikeda, H., Woods, S. C., Figlewicz, D. P., Porte, D., Greenwood, M. R. C., & Dorsa, D. M. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90166-3 · Cited by 138

Characterization of a neuronal subtype of insulin-like growth factor I receptor.

Burgess, S. K., Jacobs, S., Cuatrecasas, P., & Sahyoun, N. E. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75681-6 · Cited by 131

Immunocytochemical Detection of Insulin in Rat Hypothalamus and Its Possible Uptake from Cerebrospinal Fluid*

Baskin, D. G., Woods, S. C., West, D. B., van Houten, M., Posner, B. I., Dorsa, D. M., & Porte, D. (1983) · Endocrinology · doi:10.1210/endo-113-5-1818 · Cited by 122

Quantitative receptor autoradiography

HALL, M. D., & Davenport, A. P. (1987) · Nature · doi:10.1038/326649b0 · Cited by 114

Characterization of somatomedin/insulin-like growth factor receptors and correlation with biologic action in cultured neonatal rat astroglial cells

Han, V., Lauder, J., & D'Ercole, A. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-02-00501.1987 · Cited by 108

Quantitative Autoradiographic Evidence for Insulin Receptors in the Choroid Plexus of the Rat Brain

Baskin, D. G., Brewitt, B., Davidson, D. A., Paquette, T. L., Figlewicz, D. P., Lewellen, T. K., Graham, M. K., Woods, S. G., & Dorsa, D. M. (1986) · Diabetes · doi:10.2337/diab.35.2.246 · Cited by 104

Brain and Liver Insulin Binding Is Decreased in Zucker Rats Carrying the ’fa’ Gene*

Figlewicz, D. P., Dorsa, D. M., Stein, L. J., Baskin, D. G., Paquette, T. L., Greenwood, M. R. C., Woods, S. C., & Porte, D. (1985) · Endocrinology · doi:10.1210/endo-117-4-1537 · Cited by 91

The Failure of Rat Hypothalamic Tissues to Take up Labeled Insulin in Vivo or to Respond to Insulin in Vitro

Goodner, C. J., & Berrie, M. A. (1977) · Endocrinology · doi:10.1210/endo-101-2-605 · Cited by 83

Comparative measurements of glucose, beta-hydroxybutyrate, acetoacetate, and insulin in blood and cerebrospinal fluid during starvation

Owen, O. E., Reichard, G., Boden, G. H., & Shuman, C. R. (1974) · Metabolism · doi:10.1016/0026-0495(74)90098-5 · Cited by 79

IMMUNOREACTIVE INSULIN LEVELS ARE ELEVATED IN THE CEREBROSPINAL FLUID OF GENETICALLY OBESE ZUCKER RATS

Stein, L. J., Dorsa, D. M., Baskin, D. G., Figlewicz, D. P., Ikeda, H., Frarikmann, S. P., Greenwood, M. R. C., Porte, D., & Woods, S. C. (1983) · Endocrinology · doi:10.1210/endo-113-6-2299 · Cited by 75

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

Giddings, S. J., Chirgwin, J. M., & Permutt, M. A. (1985) · Diabetologia · doi:10.1007/bf00283141 · Cited by 69

Identification of Binding Sites for an Insulin-like Growth Factor (IGF-1) in the Median Eminence of the Rat Brain by Quantitative Autoradiography

Bohannon, N. J. V., Figlewicz, D. P., Wilcox, B. J., Porte, D., & Baskin, D. G. (1986) · Endocrinology · doi:10.1210/endo-119-2-943 · Cited by 69

Insulin receptors in rat brain cortex. Kinetic evidence for a receptor subtype in the central nervous system

Gammeltoft, S., Staun‐Olsen, P., Ottesen, B., & Fahrenkrug, J. (1984) · Peptides · doi:10.1016/0196-9781(84)90120-7 · Cited by 58

An inexpensive microcomputer digital imaging system for densitometry: quantitative autoradiography of insulin receptors with 125I and LKB ultrofilm

Baskin, D. G., Davidson, D., Lewellen, T. K., & Graham, M. M. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90044-0 · Cited by 51

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

Frank, H. J., Pardridge, W. M., Morris, W. L., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.6.654 · Cited by 51

Evidence for the role of insulin-like growth factor II (IGF-II) in the control of food intake

Lauterio, T. J., Marson, L., Daughaday, W. H., & Baile, C. A. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90279-4 · Cited by 48

Polypeptide growth factors and the CNS

Herschman, H. R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90020-2 · Cited by 47

Mediation of Insulin-Like Growth Factor Actions by the Insulin Receptor in H-35 Rat Hepatoma Cells*

Krett, N. L., Heaton, J. H., & GELEHRTER, T. D. (1987) · Endocrinology · doi:10.1210/endo-120-1-401 · Cited by 45

Proinsulin‐like material in mouse foetal brain cell cultures

Birch, N. P., Christie, D. L., & Renwick, A. G. C. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80266-5 · Cited by 45

Evidence for a subtype of insulin-like growth factor I receptor in brain

Heidenreich, K. A., Freidenberg, G. R., Figlewicz, D. P., & Gilmore, P. R. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90160-6 · Cited by 43

The distribution of somatomedins in the nervous system of the cat and their release following neural stimulation

Sara, V. R., Uvnäs‐Moberg, K., Uvnäs, B., Hall, K. E., Wetterberg, L., POSLONCEC, B., & Goiny, M. (1982) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1982.tb07105.x · Cited by 43

CNS Regulation of Carbohydrate Metabolism

(1983) · Advances in metabolic disorders · doi:10.1016/c2013-0-07074-0 · Cited by 41

Quantitative autoradiographic evidence for insulin receptors in the choroid plexus of the rat brain

Baskin, D. G., Brewitt, B., Davidson, D. A., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.2.246 · Cited by 38

Partial Purification of a Hypothalamic Factor that Inhibits Gonadotropin-Releasing Hormone-Stimulated Luteinizing Hormone Release*

HWAN, J.-C., & Freeman, M. E. (1987) · Endocrinology · doi:10.1210/endo-120-2-483 · Cited by 30

Origin of Insulin-Receptive Nerve Terminals in Rat Median Eminence*

van Houten, M., Nance, D. M., Gauthier, S. G., & Posner, B. I. (1983) · Endocrinology · doi:10.1210/endo-113-4-1393 · Cited by 29

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451

Signals That Regulate Food Intake and Energy Homeostasis

Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177

Insulin‐like growth factors I and II

HUMBEL, R. E. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15595.x · Cited by 996

Brain insulin and insulin receptors in aging and sporadic Alzheimer’s disease

Frölich, L., Blum-Degen, D., Bernstein, H.-G., Engelsberger, S., Humrich, J., Laufer, S., Muschner, D., Thalheimer, A., Türk, A., Hoyer, S., et al. (1998) · Journal of Neural Transmission · doi:10.1007/s007020050068 · Cited by 748

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 698

Insulin-Like Growth Factor Receptors in the Brain

Baskin, D. G., Bohannon, N. J. V., & Figlewicz, D. P. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5380-5_19 · Cited by 5

Insulin and insulin-like growth fadors in the CN$

Baskin, D. G., Wilcox, B. J., & Dorsa, D. M. (1988)

Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain

Hill, J. M., Lesniak, M. A., Rojeshi, M., Pert, C. B., & Roth, J. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5380-5_20 · Cited by 4

Regulation and Physiological Function of Insulin-Like Growth Factors in the Central Nervous System

Lauterio, T. J. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_37 · Cited by 7

Analysis of Insulin and Insulin-Like Growth Factor-I Receptors in Neural Tissues

Adamo, M. L., Raizada, M. K., Shemer, J., Ota, A., Sumners, C., Olson, J. A., & LeRoith, D. (2003) · Humana Press eBooks · doi:10.1385/0-89603-199-3:227