The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular interactions in macrophage activation
Abstract
Macrophage activation, broadly defined as the acquisition of competence to execute a complex function, continues to intrigue biologists, because of its fundamental importance to the host and the fascinating scientific challenges it poses. A recent meeting* emphasized the considerable progress made in this area since the topic was last considered in such a workshop. The workshop focused sharply on one aspect of the field: the molecular basis of macrophage activation, and covered the multiple, specific signals that induce and suppress activation, how these signals are transduced and thus affect macrophage behaviour and how induced function, in turn, is effected.
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“DAMPs and PAMPs (released from necrotic tissue and pathogens, respectively), as well as interferon-γ [(IFN-γ), released from natural killer cells] polarize macrophages into a pro-inflammatory phenotype [64].”
From Immunology of Wound Healing (2018) · cites this paper as [64]
Citations
Cites
Molecules, membranes and macrophage activation
Adams, D. O. (1982) · Immunology Today · doi:10.1016/0167-5699(82)90026-3 · Cited by 20
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Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.
Stemme, S., Faber, B., Holm, J., Wiklund, O., Witztum, J. L., & Hansson, G. K. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3893 · Cited by 943
Ellis, S., Lin, E. J., & Tartar, D. (2018) · Current Dermatology Reports · doi:10.1007/s13671-018-0234-9 · Cited by 625
Monocyte-mediated Tumoricidal Activity via the Tumor Necrosis Factor–related Cytokine, TRAIL
Griffith, T. S., Wiley, S. R., Kubin, M. Z., Sedger, L. M., Maliszewski, C. R., & Fanger, N. A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.8.1343 · Cited by 477
Metadata
- Authors
- Adams, D. O.
- Affiliations
- Duke Medical Center (US)
- Corresponding author
- Adams, Dolph O.
- Venue
- Immunology Today
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 10
- Issue
- 2
- Pages
- 33-35
- ISSN
- 0167-5699 (ISSN-L)
- OpenAlex
- W2066854915
- Cited by
- 101
- References
- 1
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2012: 5
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- macrophage activation, molecular signaling, signal transduction, macrophage function, host defense
- MeSH terms
- Antigen-Presenting Cells, Histocompatibility Antigens Class II, Calcium, Chemotaxis, Leukocyte, Humans, Lipopolysaccharides, Lymphokines, Macrophage Activation, Macrophages, Phagocytosis, Signal Transduction
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