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Cited by 290

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Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

Open access
Dannenberg, Arthur M.·1991·Immunology Today
DOI 10.1016/0167-5699(91)90035-r
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Abstract

It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

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Metadata

Authors
Dannenberg, A. M.
Venue
Immunology Today
Publisher
Elsevier BV
Published
1991-07
Volume
12
Issue
7
Pages
228-233
ISSN
0167-5699 (ISSN-L)
DOI
10.1016/0167-5699(91)90035-r
OpenAlex
W2092034926
Cited by
290
References
0
FWCI
10.52
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis. https://app.cochat.ai/papers/10.1016/0167-5699(91)90035-r
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Dannenberg, A. M. (1991). Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis. Immunology Today. https://doi.org/10.1016/0167-5699(91)90035-r

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.