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Cited by 391

The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.

Copper resistance mechanisms in bacteria and fungi

Open access
Cervantes, C·1994·FEMS Microbiology Reviews

Abstract

Copper is both an essential micronutrient and a toxic heavy metal for most living cells. The presence of high concentrations of cupric ions in the environment promotes the selection of microorganisms possessing genetic determinants for copper resistance. Several examples of chromosomal and plasmid copper-resistance systems in bacteria have been reported, and the mechanisms of resistance have started to be understood at the molecular level. Bacterial mechanisms of copper resistance are related to reduced copper transport, enhanced efflux of cupric ions, or copper complexation by cell components. Copper tolerance in fungi has also been ascribed to diverse mechanisms involving trapping of the metal by cell-wall components, altered uptake of copper, extracellular chelation or precipitation by secreted metabolites, and intracellular complexing by metallothioneins and phytochelatins; only the metallothionein chelation mechanism has been approached with molecular detail.

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Metadata

Authors
Cervantes, C.
Venue
FEMS Microbiology Reviews
Publisher
Wiley
Published
1994-06
Volume
14
Issue
2
Pages
121-137
ISSN
0168-6445 (ISSN-L)
OpenAlex
W2096586338
Cited by
391
References
94
FWCI
5.51
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Copper resistance mechanisms in bacteria and fungi. https://app.cochat.ai/papers/10.1016/0168-6445(94)90002-7
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Cervantes, C. (1994). Copper resistance mechanisms in bacteria and fungi. FEMS Microbiology Reviews. https://doi.org/10.1016/0168-6445(94)90002-7

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