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Cited by 355Liver Disease and TransplantationSepsis Diagnosis and TreatmentAlcohol Consumption and Health Effects

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.

Lin, Ren-Shin, Lee, Fa-Yauh, Lee, Shou-Dong, Tsai, Yang-Te, Lin, Han Chieh, Rei-Hwa, Lu, Wan-Ching, Hsu, Cheng-Chun, Huang, Sun-Sang, Wang, Kwang-Juei, Lo·1995·Journal of Hepatology
DOI 10.1016/0168-8278(95)80424-2
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Abstract

Plasma endotoxin levels were investigated using a quantitative Limulus assay in patients with chronic liver diseases and correlated with the severity of liver diseases, the presence of esophageal varices, and hemodynamic parameters. The plasma endotoxin levels were significantly higher in chronic hepatitis patients with acute exacerbation (10.1 +/- 1.3 pg/ml, n = 13, p < 0.05) and patients with cirrhosis (7.0 +/- 0.7 pg/ml, n = 126, p < 0.05) than in healthy subjects (2.9 +/- 0.2 pg/ml, n = 45). Chronic hepatitis patients (n = 30) had plasma endotoxin levels which were similar to those in healthy subjects (4.6 +/- 0.5 vs. 2.9 +/- 0.2 pg/ml, p > 0.05) but lower than those in chronic hepatitis patients with acute exacerbation (4.6 +/- 0.5 vs. 10.1 +/- 1.3 pg/ml, p < 0.05). Endotoxemia (plasma endotoxin level > 5.7 pg/ml) was found in 27%, 85% and 41% of patients with chronic hepatitis, chronic hepatitis with acute exacerbation, and cirrhosis, respectively. In patients with cirrhosis, the plasma endotoxin levels progressively increased in relation to the severity of liver dysfunction (Pugh's class A/B/C = 4.9 +/- 0.5/7.9 +/- 1.4/10.2 +/- 2.0 pg/ml, p < 0.05). In contrast, plasma endotoxin levels were comparable between patients with cirrhosis with and without esophageal varices (p > 0.05). Chronic hepatitis patients with acute exacerbation (no collaterization) had much higher plasma endotoxin levels than those in patients with cirrhosis and large varices (p < 0.05), whereas compensated patients with cirrhosis and large esophageal varices had plasma endotoxin levels similar to those seen in chronic hepatitis patients (no collaterization) (p > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1016/0168-8278(95)80424-2

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Metadata

Authors
Lin, R.-S., Lee, F.-Y., Lee, S.-D., Tsai, Y.-T., Lin, H. C., Rei-Hwa, L., Wan-Ching, H., Cheng-Chun, H., Sun-Sang, W., & Kwang-Juei, L.
Affiliations
  • Taipei Veterans General Hospital (TW)
  • National Yang Ming University (TW)
Corresponding author
Lee, Fa-Yauh
ORCID
Venue
Journal of Hepatology
Publisher
Elsevier BV
Published
1995-02
Volume
22
Issue
2
Pages
165-172
ISSN
0168-8278 (ISSN-L)
DOI
10.1016/0168-8278(95)80424-2
OpenAlex
W2155112010
Cited by
355
References
40
Citations by year
2026: 4 · 2025: 10 · 2024: 8 · 2023: 19 · 2022: 15 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 31 · 2014: 13 · 2013: 14 · 2012: 27
FWCI
4.26
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords
endotoxemia, plasma endotoxin, chronic liver disease, liver cirrhosis, chronic hepatitis, esophageal varices, hyperdynamic circulation, portal hypertension, acute exacerbation, liver dysfunction severity, collateral circulation
MeSH terms
Blood Circulation, Chronic Disease, Endotoxins, Esophageal and Gastric Varices, Female, Hepatitis, Humans, Liver Cirrhosis, Liver Diseases, Male, Middle Aged

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