Position-effect variegation after 60 years
Abstract
Position-effect variegation in Drosophila--the mosaic expression of a gene placed adjacent to a junction between euchromatin and heterochromatin--remains an enigma. However, new insights are being gained from recent studies of genetic modifiers, new model systems, and variegating genes showing exceptional behavior.
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Approximately one-third of the Drosophila modifier genes have been identified, and most play critical roles in epigenetic gene silencing.
“Approximately one-third of these have been identified and, as expected, most turn out to play critical roles in epigenetic gene silencing [1,9].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [1]
The Drosophila wv strain displays variegated expression of the white locus, resulting in red and white patches in the eye.
“The screens used a fly strain, called wv, that displays variegated expression of the white (w) locus resulting in red and white patches in the eye.”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [1]
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References 30 · Cited by 280
- Authors
- Henikoff, S.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Henikoff, Steven
- ORCID
- Henikoff, Steven
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1990
- Volume
- 6
- Issue
- 12
- Pages
- 422-426
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2056870821
- Cited by
- 280
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 7 · 2012: 7
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- position effect variegation, Drosophila, euchromatin, heterochromatin, genetic modifiers, chromatin structure
- MeSH terms
- Animals, Chromosomes, Drosophila, Heterochromatin, Mosaicism, Gene Expression
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