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Cited by 12Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

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Murine central neurons express a novel member of the cdc10/SW16 motif-containing protein superfamily

Fujigasaki, Hiroto, Song, Si-Young, Kobayashi, Takayoshi, Yamakuni, Tohru·1996·Molecular Brain Research
DOI 10.1016/0169-328x(96)00005-8
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Abstract

V-1 protein is a novel member of the cdc10/SWI6 motif-containing protein superfamily several members of which have been demonstrated to play crucial roles in the regulation of intracellular signaling. In the present study we examined the distribution of V-1 mRNA in the murine central nervous system (CNS). Northern analysis revealed the expression of V-1 mRNA in various regions of the brain with the following rank order: hippocampus, cerebellum > cerebral cortex, olfactory bulb, medulla oblongata, pons > thalamus. In situ hybridization also showed that V-1 mRNA is widely distributed in various regions of the brain, with parallel expression levels to those revealed by Northern analysis. Immunohistochemical analysis revealed that the V-1 protein exists in various types of neurons, mainly in cell bodies but also in dendrites, axons and possibly in synaptic areas. These expression patterns of the V-1 gene in the murine CNS suggest that the V-1 protein performs some common function in different classes of neurons. We found no significant difference in the expression level of V-1 mRNA in cerebellar granule cells between the control and mutant mice of Purkinje cell degeneration (pcd). In comparison with our previous data obtained in another mutant, staggerer, we discussed the effects of target deprivation on the expression of V-1 mRNA in cerebellar granule cells.

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  • Luciferase reporter assays have identified myotrophin (Mtpn) as a target of miR-124 regulation, both of which are highly expressed in neurons throughout the brain.

    “Additionally, luciferase reporter assays have identi-fied myotrophin (Mtpn) as a target of miR-124 regulation (Krek et al. 2005), both of which are highly expressed in neurons throughout the brain (Fujigasaki et al. 1996).”

    From MicroRNA expression in the adult mouse central nervous system (2008) · cites this paper as Fujigasaki et al. 1996

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Metadata

Authors
Fujigasaki, H., Song, S.-Y., Kobayashi, T., & Yamakuni, T.
Affiliations
Tokyo Medical and Dental University (JP)
Corresponding author
Yamakuni, Tohru
ORCID
Venue
Molecular Brain Research
Publisher
Elsevier BV
Published
1996-09
Volume
40
Issue
2
Pages
203-213
ISSN
0169-328X (ISSN-L)
DOI
10.1016/0169-328x(96)00005-8
OpenAlex
W1992847027
Cited by
12
References
0
Citations by year
2012: 1
FWCI
0.25
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
central nervous system neurons, cerebellar granule cells
MeSH terms
Animals, Autoradiography, Central Nervous System, Cerebral Cortex, Immunohistochemistry, Male, Mice, Inbred Strains, Mutation, Nerve Tissue Proteins, Blotting, Western, Gene Expression, Rats, Wistar, In Situ Hybridization, Intercellular Signaling Peptides and Proteins, Mice, Rats

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