Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics
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Factors that can contribute to incomplete bioavailability of subcutaneously injected molecules include the composition, volume, pH, and viscosity of the dosing formulation; interactions with interstitial glycosaminoglycans and proteins; and enzymatic degradation.
“Other factors that can contribute to incomplete bioavailability of subcutaneously injected molecules can include the composition, volume, pH, and viscosity of the dosing formulation; interactions with interstitial glycosaminoglycans and proteins; and enzymatic degradation [70, 72, 73].”
From Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities (2018) · cites this paper as [73]
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References 82 · Cited by 183
- Authors
- Hawley, A. E., Davis, S. S., & Illum, L.
- Affiliations
- University of Nottingham (GB)
- Corresponding author
- Davis, S.S.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 17
- Issue
- 1
- Pages
- 129-148
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2069711409
- Cited by
- 183
- References
- 82
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 12 · 2017: 2 · 2016: 9 · 2015: 11 · 2014: 9 · 2013: 14 · 2012: 8
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- lymph node targeting, colloids, lymphatic physiology, lymphatic absorption, subcutaneous administration, route of administration, regional lymph nodes, drug delivery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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