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Cited by 31Liver physiology and pathologyOrgan Transplantation Techniques and OutcomesDrug-Induced Hepatotoxicity and Protection

Regulation of liver regeneration by interleukin-2 and its inhibitors: Cyclosporine A and FK 506

Tanaka, Noriaki, Yamamoto, Hiroshi, Tatemoto, Akihiko, Urabe, Takamitsu, Orita, Kunzo·1993·International Journal of Immunopharmacology
DOI 10.1016/0192-0561(93)90097-i
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Abstract

Several investigations have been suggesting that lymphocytes can be responsible for growth regulation of liver. The interleukin-2 (IL-2) production by spleen cells was noted to be increased 2 days after resection of 70% of the volume of the liver in C3H/He mice. The effects of IL-2 production and its antagonists: cyclosporine A (CsA) and FK506 on liver regeneration were thus studied by measuring in vivo incorporation of Bromodeoxyuridine (BrdU). By intraperitoneal injection of IL-2 5 times every 8 h after hepatectomy. BrdU labeling indices at 36 h after the operation were suppressed in a dose-dependent manner. On the other hand, treatment with CsA and FK506, which inhibit IL-2 production, increased the mitotic indices of the regenerating livers. Serum levels of aminotransferases were not affected by FK506 at a dose sufficient for the mitotic stimulation. Based on these results, CsA and FK506 would appear to stimulate liver cell proliferation by suppressing IL-2 production and inhibiting of NK cell activity.

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Crossref · 10.1016/0192-0561(93)90097-i

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  • Elevated concentrations of IL-2 and IL-18 contribute to inhibiting liver growth and downregulating regenerative processes.

    “Additionally, elevated concentrations of IL-2 and IL-18 contribute to inhibiting liver growth and downregulating regenerative processes[98,99].”

    From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [98]

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Authors
Tanaka, N., Yamamoto, H., Tatemoto, A., Urabe, T., & Orita, K.
Affiliations
Okayama University (JP)
Corresponding author
Tanaka, Noriaki
ORCID
Yamamoto, Hiroshi
Venue
International Journal of Immunopharmacology
Publisher
Elsevier BV
Published
1993-02
Volume
15
Issue
2
Pages
211-218
ISSN
0192-0561 (ISSN-L)
DOI
10.1016/0192-0561(93)90097-i
OpenAlex
W2067435893
Cited by
31
References
0
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2017: 1 · 2016: 2 · 2014: 1 · 2012: 1
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords
liver regeneration, interleukin-2, cyclosporine, FK506, hepatectomy, liver cell proliferation, mitotic index, NK cell cytotoxicity, transaminases, C3H/He mice
MeSH terms
Animals, Hepatectomy, Interleukin-2, Killer Cells, Natural, Liver Regeneration, Male, Mice, Inbred C3H, Spleen, Killer Cells, Lymphokine-Activated, Tacrolimus, Cyclosporine, Mice

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