The DOI matches its Crossref record; 41 of the 43 references it cites were found in a registry or an index.
Interleukin-8 and the chemokine family
Abstract
Two subfamilies of chemokines are distinguished depending on the arrangement of the first two of four conserved cysteines, which are either separated by one amino acid (CXC chemokines) or adjacent (CC chemokines). IL-8 and the other CXC chemokines act preferentially on neutrophils, while the CC chemokines (MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta) act on monocytes, but not neutrophils, and have additional activities toward basophil and eosinophil granulocytes, and T-lymphocytes. Several chemokine receptors have been identified, all of which belong to the seven-transmembrane-domain type and are coupled to G-proteins. The discovery of chemokines has provided the basis for the understanding of leukocyte recruitment and activation in inflammation and other disturbances of tissue homeostasis.
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“Concurrent with the achievement of hemostasis, neutrophils are the first cells to migrate to the wound bed, brought in by pro-inflammatory signals including IL-8.”
From Immunology of Wound Healing (2018) · cites this paper as [31]
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Metadata
- Authors
- Baggiolini, M., Loetscher, P., & Moser, B.
- Affiliations
- University of Bern (CH)
- Venue
- International Journal of Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 17
- Issue
- 2
- Pages
- 103-108
- ISSN
- 0192-0561 (ISSN-L)
- OpenAlex
- W2017132882
- Cited by
- 400
- References
- 43
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 13 · 2021: 9 · 2020: 14 · 2019: 17 · 2018: 5 · 2017: 6 · 2016: 14 · 2015: 16 · 2014: 13 · 2013: 11 · 2012: 14
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-8, chemokines, CXC chemokines, CC chemokines, chemokine receptors, G protein-coupled receptors, G proteins, leukocyte recruitment, inflammation, neutrophils, monocytes, basophils, eosinophils, T cells
- MeSH terms
- Animals, Calcium, Chemotactic Factors, Humans, Inflammation, Leukocytes, Cytokines, Interleukin-8, Respiratory Burst, Receptors, Interleukin, Neutrophil Activation, Receptors, Interleukin-8A
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