Corticotropin-releasing factor administered intraventricularly to rhesus monkeys
Abstract
Synthetic ovine corticotropin-releasing factor (CRF) administered intraventricularly (ICV) to rhesus monkeys resulted in endocrine and behavioral changes. At doses of 20 and 180 micrograms, CRF stimulated the pituitary-adrenal axis in four chair-restrained monkeys. These monkeys showed concomitant increases in arousal. To study these animals in a less restrictive setting, three of the monkeys later received CRF ICV (20 and 180 micrograms) in their home cages. At the 180-micrograms dose the monkeys exhibited a combination of huddling and lying down behavior. These behavioral effects did not seem to be due to alterations in blood pressure.
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CRH raises blood pressure when administered intraventricularly.
“Because CRH raises blood pressure when administered intraventricularly, it has been proposed that the elevated CRH levels in hypertensive patients may contribute to their hypertension (Kalin et al., 1983).”
From The impact of the circadian timing system on cardiovascular and metabolic function (2012) · cites this paper as Kalin et al., 1983
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References 27 · Cited by 101
- Authors
- Kalin, N. H., Shelton, S. E., Kraemer, G. W., & McKinney, W. T.
- Affiliations
- William S. Middleton Memorial Veterans Hospital (US)
- University of Wisconsin–Madison (US)
- ORCID
- Kalin, Ned H.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1983-03
- Volume
- 4
- Issue
- 2
- Pages
- 217-220
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W1996024414
- Cited by
- 101
- References
- 27
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2012: 3
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- corticotropin-releasing factor, intraventricular administration, rhesus monkeys, pituitary-adrenal axis, stress response, arousal, huddling behavior, lying behavior, blood pressure, home cage behavior
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Behavior, Animal, Blood Pressure, Corticotropin-Releasing Hormone, Exploratory Behavior, Heart Rate, Hydrocortisone, Injections, Intraventricular, Macaca mulatta, Male, Motor Activity, Pituitary-Adrenal System, Restraint, Physical
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