Circadian and seasonal rhythms of 5-HT receptor subtypes, membrane anisotropy and 5-HT release in hippocampus and cortex of the rat
Abstract
Specific serotonin binding (5-HT1, 5-HT1A, and 5-HT2 subtypes) and membrane anisotropy were measured at 2 h intervals over a 24 h period in the hippocampus and cortex of Wistar WU rats, housed under a 12 h light-dark cycle, with lights on at 07.00. All experiments were performed both in March and December. In the hippocampus significant circadian rhythms could be ascertained for 5-HT1 binding sites in March and December while for 5-HT1A (subtype of 5-HT1) binding sites the circadian rhythm was only significant in March. The membrane anisotropy also showed significant variations only in March. Circadian rhythms were also found in the cortex for 5-HT1 (December) and 5-HT2 (March and December) binding sites as well as for the membrane anisotropy (December). A correlation was found between membrane anisotropy and 5-HT1 and 5-HT2 binding sites in hippocampus and cortex, respectively. A circadian rhythmicity was also observed for serotonin release as measured by in vivo voltammetry in both brain areas. The results obtained on the diurnal variations of serotonin receptor subtypes and serotonin release and the probable inverse relationship of these two parameters may be relevant in understanding the coupling of pre- and postsynaptic activity.
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Major neurotransmitters implicated in mood regulation, including serotonin, norepinephrine, and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes.
“Indeed some of the major neurotransmitters that have been implicated in mood regulation, including serotonin, norepinephrine and dopamine, have a circadian rhythm in their levels, release, and synthesis-related enzymes (Weiner et al., 1992; Shieh et al., 1997; Aston-Jones et al., 2001; Barassin et al., 2002; Khaldy et al., 2002; Castaneda et al., 2004; Weber et al., 2004; Malek et al., 2005).”
From Circadian genes, rhythms and the biology of mood disorders (2007) · cites this paper as Weiner et al., 1992
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References 35 · Cited by 43
- Authors
- Weiner, N., Clement, H.-W., Gemsa, D., & Wesemann, W.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Wesemann, W.
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 21
- Issue
- 1
- Pages
- 7-14
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2061640164
- Cited by
- 43
- References
- 35
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- serotonin receptors, 5-HT1 receptors, 5-HT1A receptor, 5-HT2 receptor, circadian rhythm, seasonal variation, membrane anisotropy, serotonin release, hippocampus, cerebral cortex, light-dark cycle
- MeSH terms
- Analysis of Variance, Animals, Cell Membrane, Cerebral Cortex, Circadian Rhythm, Darkness, Hippocampus, Ketanserin, Light, Male, Membrane Potentials, Organ Specificity, Periodicity, Pyrimidines, Receptors, Serotonin, Seasons, Serotonin, Anti-Anxiety Agents, Rats, Wistar, Rats
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