Quantitative changes in cerebral cortical microvasculature in ageing and dementia
Abstract
Brains were obtained postmortem from 25 mentally normal patients aged 26 to 96 years and from 3 patients with Alzheimer's disease. Although the number of pyramidal nerve cells within frontal and temporal cortex decreased significantly with age, measures of capillary density correlated only weakly with age. Stronger correlations, however, were noted between measures of capillary density and number of pyramidal cells, irrespective of age or disease. Capillary measures did not differ in 6 of the mentally normal patients who showed a few plaques and tangles in their cortex from those of 6 other patients of similar age who did not show such changes. It is concluded that the extent of the capillary network in the cerebral cortex alters to match the number and activity of functioning nerve cells; changes in quantity of capillary occurring with age or Alzheimer's disease may, therefore, secondarily reflect a primary loss of nerve cells and do not form, per se, part of the degenerative process.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The endothelial component of TSPO PET, which is dependent on the vascular density in the brain, differs between regions, and may change with ageing and pathology.
“Moreover, the endothelial component of TSPO PET, which is dependent on the vascular density in the brain, differs between regions, and may change with ageing and pathology (Mann et al., 1986; Veronese et al., 2018; Wimberley et al., 2018).”
From A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis (2019) · cites this paper as Mann et al., 1986
The citation lists haven’t been fetched yet
References 33 · Cited by 74
- Authors
- Mann, D. M. A., Eaves, N. R., Marcyniuk, B., & Yates, P. O.
- Affiliations
- University of Manchester (GB)
- ORCID
- Mann, David M.A.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1986-09
- Volume
- 7
- Issue
- 5
- Pages
- 321-330
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2021625064
- Cited by
- 74
- References
- 33
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 5 · 2016: 3 · 2014: 2 · 2012: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- capillary density, aging, dementia, Alzheimer's disease, pyramidal neurons, neuronal loss, cerebral cortex, postmortem brain, amyloid plaques, neurofibrillary tangles, cerebral blood flow
- MeSH terms
- Adult, Aged, Aging, Alzheimer Disease, Capillaries, Cell Count, Intracranial Arteriosclerosis, Cerebral Cortex, Female, Humans, Hypertension, Male, Middle Aged, Neurofibrils, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
