VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease
Abstract
The brains of 46 control subjects and 21 Alzheimer's disease (AD) patients were studied to determine whether there are age-related or AD-related changes in the vasoactive intestinal polypeptide (VIP) neuron population of the human suprachiasmatic nucleus (SCN). The number of VIP expressing neurons in the SCN of females, ranging in age from 10-91 years, did not change during normal aging. In males, however, the number of VIP neurons in the SCN was highest in the young subjects (10-40 years of age), after which, a dramatic decrease occurred in middle-aged subjects. This resulted in an age-dependent sex difference in the VIP cell population of the SCN: young males had twice as many VIP expressing SCN neurons as young females, whereas in the middle-aged groups, the females had twice as many VIP SCN neurons as the males. A significant decrease in the number of VIP expressing neurons in the SCN was found in female presenile AD patients, i.e., those younger than 65 years.
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The number of vasopressin-expressing cells in the SCN in humans and rodents reduces with age, possibly altering SCN output.
“The number of vasopressin-expressing cells in the SCN in humans243,244 and rodents245,246 reduces with age, possibly altering SCN output.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [244]
AD brains show marked loss of neurons in the SCN, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death.
“AD brains show marked loss of neurons in the SCN243,244,262, and SCN neuronal loss correlates with reductions in the amplitude of motor activity rhythms in the same individuals before death240.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [244]
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References 40 · Cited by 243
- Authors
- Zhou, J.
- Affiliations
- Ningxia Medical University (CN)
- Corresponding author
- Zhou, J
- ORCID
- Zhou, J
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 16
- Issue
- 4
- Pages
- 571-576
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2023689431
- Cited by
- 243
- References
- 40
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 21 · 2020: 18 · 2019: 15 · 2018: 8 · 2017: 14 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- vasoactive intestinal peptide, suprachiasmatic nucleus, Alzheimer's disease, sex differences, age-related changes, VIP neurons, neurodegeneration, circadian rhythm
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cell Count, Child, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Sex Factors, Suprachiasmatic Nucleus, Vasoactive Intestinal Peptide
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