Cited by 169Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersVitamin C and Antioxidants Research

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

A preliminary trial of ascorbic acid as supplemental therapy for autism

Dolske, Michelle Cobb, Spollen, John, McKay, Sean, Lancashire, Elizabeth, Tolbert, Lelland·1993·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/0278-5846(93)90058-z

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Abstract

1. This study presents the results of a 30-week double-blind, placebo-controlled trial exploring the effectiveness of ascorbic acid (8g/70kg/day) as a supplemental pharmacological treatment for autistic children in residential treatment. 2. Residential school children (N = 18) were randomly assigned to either ascorbate-ascorbate-placebo treatment order group or ascorbate-placebo-ascorbate treatment order group. Each treatment phase lasted 10 weeks and behaviors were rated weekly using the Ritvo-Freeman scale. 3. Significant group by phase interactions were found for total scores and also sensory motor scores indicating a reduction in symptom severity associated with the ascorbic acid treatment. 4. These results were consistent with a hypothesized dopaminergic mechanism of action of ascorbic acid.

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Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,020
Brain dopamine receptors.
Seeman, P. M. (1980) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06839-5 · Cited by 1,888
Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms
Anderson, L. T., Campbell, M., Grega, D. M., Perry, R., Small, A. M., & Green, W. H. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.10.1195 · Cited by 323
Psychopharmacology in Child and Adolescent Psychiatry: A Review of the Past Five Years
Campbell, M., & SPENCER, E. K. (1988) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198805000-00001 · Cited by 182
A Scale for Rating Symptoms of Patients with the Syndrome of Autism in Real Life Settings
Freeman, B. J., RITVO, E. R., Yokota, A., & Ritvo, A. (1986) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60610-5 · Cited by 143
Effect of ascorbic acid on neurochemical, behavioral, and physiological systems mediated by catecholamines
Tolbert, L. C., Thomas, T. N., Middaugh, L. D., & Zemp, J. W. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90091-2 · Cited by 96
Ascorbic acid could be hazardous to your experiments: A commentary on dopamine receptor binding studies with speculation on a role for ascorbic acid in neuronal function
Hadjiconstantinou, M., & Neff, N. H. (1983) · Neuropharmacology · doi:10.1016/0028-3908(83)90209-5 · Cited by 74
Ascorbic Acid and the Behavioral Response to Haloperidol: Implications for the Action of Antipsychotic Drugs
Rebec, G. V., Centore, J. M., White, L. K., & Alloway, K. D. (1985) · Science · doi:10.1126/science.4038426 · Cited by 71
Modulation of neostriatal activity by iontophoresis of ascorbic acid
Gardiner, T. W., Armstrong‐James, M., Caan, A. W., Wightman, R. M., & Rebec, G. V. (1985) · Brain Research · doi:10.1016/0006-8993(85)91207-7 · Cited by 52
Ascorbate blocks amphetamine-induced turning behavior in rats with unilateral nigro-striatal lesions
Tolbert, L. C., Thomas, T. N., Middaugh, L. D., & Zemp, J. W. (1979) · Brain Research Bulletin · doi:10.1016/0361-9230(79)90056-x · Cited by 46

Show all 19 references

Research works printed but not linked: 3

Tolbert, 1990, Comparison of the selectivity and specificity of ascorbic acid antagonism of dopaminergic agonist binding, Soc. Neurosci. Abstr., 16, 80
Tolbert, 1989, Effects of ascorbic acid, isoascorbic acid, and gluroascorbic acid on the binding of the D2 agonist 3H-N-0437, Soc. Neurosci. Abstr., 15, 425
Tolbert, 1979, Ascorbate effects conversion of tyrosine to dopamine in mouse brain, Trans. Amer. Soc. Neurochem., 10, 184

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Authors: Dolske, M. C., Spollen, J., McKay, S., Lancashire, E., & Tolbert, L.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Spollen, John
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 1993-09
Volume: 17
Issue: 5
Pages: 765-774
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/0278-5846(93)90058-z
OpenAlex: W2083633216
Cited by: 168
References: 19
Citations by year: 2026: 2 · 2025: 1 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 5 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 12 · 2014: 15 · 2013: 5 · 2012: 11
FWCI: 0.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Keywords: vitamin C, vitamin C supplementation, autism spectrum disorder, children with autism, residential treatment, sensory-motor behavior, dopaminergic mechanisms
MeSH terms: Adolescent, Adult, Ascorbic Acid, Autistic Disorder, Child, Double-Blind Method, Female, Humans, Male, Psychiatric Status Rating Scales

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A preliminary trial of ascorbic acid as supplemental therapy for autism

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