Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 73

The DOI matches its Crossref record.

Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria

Ohta, T., Watanabe, M., Watanabe, K., Shirasu, Y., Kada, T.·1986·Food and Chemical Toxicology
DOI 10.1016/0278-6915(86)90264-4
Open this paper in CoChat — free account

Abstract

The antimutagenic potential of twenty-five flavourings was tested against the activity of several kinds of chemical mutagens in Escherichia coli and Salmonella typhimurium. Anisaldehyde, ethylvanillin and vanillin showed marked antimutagenic effects on mutagenesis induced by 4-nitroquinoline 1-oxide, furylfuramide (AF-2), captan or methylglyoxal in E. coli WP2s. However, they were not effective against mutations provoked by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in S. typhimurium TA98. Despite the decrease in the number of mutants, a remarkable increase was observed in the survival of mutagen-treated WP2s cells after exposure to these flavourings. We assume that these compounds may act as bio-antimutagens by enhancing an error-free recombinational repair system, because this reactivation of survival was strictly dependent on the recA gene function but not on the lexA and uvrA gene functions.

Overview

Integrity signals

Registry

Crossref · 10.1016/0278-6915(86)90264-4

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 15

  1. Ames, 1975, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test, Mutation Res., 31, 347, 10.1016/0165-1161(75)90046-1 · DOI
  2. Arimoto, 1980, Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments, Biochem. biophys. Res. Commun., 92, 662, 10.1016/0006-291X(80)90384-8 · DOI
  3. Gottesman, 1981, Genetic control of the SOS system in, Cell, 23, 1, 10.1016/0092-8674(81)90261-0 · DOI
  4. Kada, 1981, Antimutagenic activities of human placental extract on ultraviolet light- and gamma-ray-induced mutation in Escherichia coli WP2 B/r trp., J. Radiat. Res., 22, 297, 10.1269/jrr.22.297 · DOI
  5. Kada, 1984, Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538, Mutation Res., 125, 145, 10.1016/0027-5107(84)90066-6 · DOI
  6. Kakinuma, 1984, Cinnamaldehyde: Identification of an antimutagen from a crude drug, cinnamoni cortex, Agric. biol. Chem., 48, 1905
  7. Kakinuma, 1984, Antimutagenic diterpenoids from a crude drug isodonis herba (enmei-so), Agric. biol. Chem., 48, 1647
  8. Kasai, 1982, Mutagenicity of methylglyoxal in coffee, Gann, 73, 681
  9. Little, 1982, The SOS regulatory system of Escherichia coli, Cell, 29, 11, 10.1016/0092-8674(82)90085-X · DOI
  10. Minakata, 1983, Protoanemonin, an antimutagen isolated from plants, Mutation Res., 116, 317, 10.1016/0165-1218(83)90069-1 · DOI
  11. Ohta, 1984, The SOS-function-inducing activity of chemical mutagens in Escherichia coli, Mutation Res., 131, 101, 10.1016/0167-8817(84)90048-8 · DOI
  12. Ohta, 1983, Antimutagenic effects of cinnamaldehyde on chemical mutagenesis in Escherichia coli, Mutation Res., 107, 219, 10.1016/0027-5107(83)90164-1 · DOI
  13. Ohta, 1983, Antimutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli, Mutation Res., 117, 135, 10.1016/0165-1218(83)90160-X · DOI
  14. Ohta, 1983, Analysis of the antimutagenic effect of cinnamaldehyde on chemically induced mutagenesis in Escherichia coli, Molec. gen. Genet., 192, 309, 10.1007/BF00392167 · DOI
  15. Witkin, 1976, Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli, Bact. Rev., 40, 869, 10.1128/br.40.4.869-907.1976 · DOI

Cited by

Metadata

Authors
Ohta, T., Watanabe, M., Watanabe, K., Shirasu, Y., & Kada, T.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
1986-01
Volume
24
Issue
1
Pages
51-54
ISSN
0278-6915
DOI
10.1016/0278-6915(86)90264-4
Cited by
73
References
0
Language
en
Licence
Funders
  • Ministerie van Onderwijs, Cultuur en Wetenschap
  • Ministry of Health, Labour and Welfare

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.