The DOI matches its Crossref record; 23 of the 27 references it cites were found in a registry or an index.
Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following γ-irradiation
Abstract
A nuclear poly(ADP-ribose) polymerase (PARP) is activated by gamma-irradiation and consequently synthesizes poly(ADP-ribose) by binding to DNA strand-breaks. This property suggests that PARP is a DNA strand-break-signal generator. Meanwhile, the cell-cycle arrest occurs in G1 and G2 phases following gamma-irradiation. We found that PARP inhibitors including 3-aminobenzamide (3-AB) suppressed G1 arrest and enhanced G2 arrest following gamma-irradiation. These observations suggested that PARP is critical for the induction of G1 arrest and is also involved in the regulation of G2 arrest. Furthermore, the effects of 3-AB on the G1-arrest signal-transduction pathway were also studied. We found that p53 stabilization following gamma-irradiation was not inhibited but the p53-responsive transient increases of WAF1/CIP1/p21 and MDM-2 mRNA were suppressed by 3-AB. Therefore, it is suggested that PARP participates in G1-arrest signal-transduction pathway through the modulation of WAF1/CIP1/p21 and MDM-2 mRNA expression.
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“These processes are well-known to happen in response to PARP inhibition and depict the biggest part of the network (Ray Chaudhuri and Nussenzweig, 2017; Masutani et al, 1995).”
From Network integration of thermal proteome profiling with multi-omics data decodes PARP inhibition (2024) · cites this paper as Masutani et al, 1995
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WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
Oliner, J. D., Pietenpol, J. A., Thiagalingam, S., Gyuris, J., Kinzler, K. W., & Vogelstein, B. (1993) · Nature · doi:10.1038/362857a0 · Cited by 1,474
Dulić, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., & Reed, S. I. (1994) · Cell · doi:10.1016/0092-8674(94)90379-4 · Cited by 1,465
Creative blocks: cell-cycle checkpoints and feedback controls
Murray, A. W. (1992) · Nature · doi:10.1038/359599a0 · Cited by 660
ADP-ribosylation of proteins. Enzymology and biological significance.
Althaus, F. R., & Richter, C. (1987) · PubMed · Cited by 371
14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast
Ford, J. C., Al-Khodairy, F. M., Fotou, E., Sheldrick, K. S., Griffiths, D. J. F., & Carr, A. M. (1994) · Science · doi:10.1126/science.8036497 · Cited by 335
Juven‐Gershon, T., Barak, Y., Zauberman, A., George, D. L., & Oren, M. (1993) · PubMed · Cited by 332
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4 of the 27 references couldn’t be matched to a known paper.
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PARP is important for genomic stability but dispensable in apoptosisPreprint
Wang, Z., Stingl, L., Morrison, C. G., Jantsch, M. F., Łoś, M., Schulze‐Osthoff, K., & Wagner, E. F. (1997) · Genes & Development · doi:10.1101/gad.11.18.2347 · Cited by 557
Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins
Pleschke, J. M., Kleczkowska, H. E., Strohm, M., & Althaus, F. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006520200 · Cited by 564
Molecular mechanisms of ionizing radiation‐induced apoptosis
Watters, D. J. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00824.x · Cited by 138
Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice
Masutani, M., Nozaki, T., Nishiyama, E., Shimokawa, T., Tachi, Y., Suzuki, H. I., Nakagama, H., Wakabayashi, K., & Sügimura, T. (1999) · Springer eBooks · doi:10.1007/978-1-4419-8740-2_21 · Cited by 127
Self-citationApoptosis in the heart: when and why?
Brömme, H. J., & Holtz, J. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00408667 · Cited by 121
Metadata
- Authors
- Masutani, M., Nozaki, T., Wakabayashi, K., & Sugimura, T.
- Affiliations
- National Cancer Center Research Institute (JP)
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 1995
- Volume
- 77
- Issue
- 6
- Pages
- 462-465
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W1965795362
- Cited by
- 61
- References
- 27
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1
- FWCI
- 1.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimie (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, Labour and Welfare
- Foundation for Promotion of Cancer Research
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- poly(ADP-ribose) polymerase, gamma irradiation, cell cycle checkpoints, G1 cell cycle arrest, G2 cell cycle arrest, 3-aminobenzamide, PARP inhibitors, DNA strand breaks, p53 stabilization, MDM2, signal transduction, DNA damage response
- MeSH terms
- Poly(ADP-ribose) Polymerase Inhibitors, Animals, DNA Damage, Enzyme Activation, Gamma Rays, Humans, Poly(ADP-ribose) Polymerases, Radiation-Sensitizing Agents, Signal Transduction, G1 Phase, G2 Phase
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