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Cited by 198Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

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Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?

Jones, R.S.G.·1982·Progress in Neurobiology
DOI 10.1016/0301-0082(82)90023-5
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Abstract

Tryptamine synthesized by decarboxylation of L-tryptophan occurs as an endogenous constituent of mammalian brain albeit at very low concentrations (low ng/g range). It is primarily metabolized by oxidative deamination by MAO and possesses an extremely rapid turnover and half-life. Subcellular localization appears to be in nerve terminals and it is releasable by electrical or potassium evoked depolarization. Neuropharmacological and electrophysiological data strongly suggest the existence of post-synaptic receptors for tryptamine independent of those for 5HT. There may exist a rostrally projecting neuronal tryptamine containing system arising from cell bodies in or close to the nucleus raphé medianus. The demonstration of specific receptors for tryptamine in the CNS strongly indicates a transmitter role, although a strong case can be made for a role as a modifier of central 5HT systems. The possibility also exists that 5HT and tryptamine may be mediators of functionally opposite neuronal pathways. Whatever the role of tryptamine in the CNS it is clear that it not simply present as an accident of metabolism or a "biological artefact." The indications are that it possesses important functions in central neurotransmission.

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Authors
Jones, R. S. G.
Corresponding author
Jones, R.S.G.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
1982-01
Volume
19
Issue
1-2
Pages
117-139
ISSN
0301-0082 (ISSN-L)
DOI
10.1016/0301-0082(82)90023-5
OpenAlex
W2046097464
Cited by
198
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 10 · 2023: 10 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 7 · 2016: 4 · 2015: 4 · 2014: 9 · 2013: 7 · 2012: 4
FWCI
3.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
tryptamine, neurotransmitters, neuromodulators, monoamine oxidase, oxidative deamination, tryptamine receptors, serotonin, presynaptic terminals, synaptic transmission
MeSH terms
Animals, Behavior, Animal, Body Temperature Regulation, Brain, Brain Mapping, Electroencephalography, Evoked Potentials, Humans, Monoamine Oxidase, Neural Inhibition, Synaptic Transmission, Neurons, Serotonin, Spinal Cord, Tryptamines, Neurotransmitter Agents

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