A ketamine-induced rat model of tardive dyskinesia
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NMDA-receptor antagonists such as MK801, ketamine, and phencyclidine cause symptoms similar to anti-NMDA-receptor encephalitis, including psychotic behaviour, signs of involvement of dopaminergic pathways, and autonomic dysfunction.
“Consistent with this antibody-induced decrease in the numbers of NMDA receptors, several NMDA-receptor antagonists such as MK801, ketamine, and phencyclidine cause symptoms similar to anti-NMDA-receptor encephalitis, including psychotic behaviour,21,22 signs of involvement of dopaminergic pathways (rigidity, dystonia, orofacial movements, tremor)22–25 and autonomic dysfunction (cardiac dysrhythmia”
From Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies (2008) · cites this paper as [24]
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References 105 · Cited by 10
- Authors
- Marco, L. A., & Joshi, R. S.
- Affiliations
- University of South Alabama (US)
- ORCID
- Joshi, R.S.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 38
- Issue
- 6
- Pages
- 571-600
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2040229051
- Cited by
- 10
- References
- 105
- Citations by year
- 2026: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (5 R01NS 2457)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- tardive dyskinesia, ketamine, animal models, NMDA receptor antibodies, LGI1 antibodies, autoimmune encephalitis, aquaporin-4 antibodies, myelin oligodendrocyte glycoprotein antibodies, complement fixation, immunotherapy
- MeSH terms
- Animals, Clozapine, Dyskinesia, Drug-Induced, Haloperidol, Ketamine, Metoclopramide, Pharynx, Rats, Inbred Strains, Stereotyped Behavior, Tongue, Antipsychotic Agents, Dizocilpine Maleate, Rats
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