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Cited by 174Thyroid Disorders and TreatmentsProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and Signaling

Dual activation by thyrotropin of the phospholipase c and cyclic AMP cascades in human thyroid

Laurent, E., Mockel, J., Van Sande, J., Graff, I., Dumont, J.E.·1987·Molecular and Cellular Endocrinology
DOI 10.1016/0303-7207(87)90055-4
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Abstract

In human thyroid slices prelabeled with myo-[2-3H]inositol, thyrotropin (TSH, 3-30 mU/ml) stimulated IP3, IP2 and IP1 generation over a prolonged time course. The cAMP response was much more sensitive to TSH, peaking between 1 and 5 mU/ml. Forskolin (10(-5) M) and isoproterenol had no effect on basal IP levels, while carbamylcholine (10(-5) M, 10(-4) M) also increased IP accumulation. These data suggest that in the human thyroid, TSH activates a phospholipase C generating IP3 and diacylglycerol independently of the well-known adenylate cyclase stimulation. They validate in the human model a dual mode of action of the hormone previously proposed on the basis of indirect observations.

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  • It takes 10 times higher concentrations of TSH to activate Gαq/11 and the downstream phospholipase C (PLC) and inositol-1,4,5-trisphosphate (IP3) than to activate cAMP in human thyroid slices.

    “It was reported that it takes 10 times higher concentrations of TSH to activate Gαq/11 and the downstream phospholipase C (PLC) and inositol-1,4,5-trisphosphate (IP3) than to activate cAMP in human thyroid slices (117).”

    From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [117]

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Authors
Laurent, E., Mockel, J., Van Sande, J., Graff, I., & Dumont, J. E.
Affiliations
Erasmus Hospital (BE)
Venue
Molecular and Cellular Endocrinology
Publisher
Elsevier BV
Published
1987-08
Volume
52
Issue
3
Pages
273-278
ISSN
0303-7207 (ISSN-L)
DOI
10.1016/0303-7207(87)90055-4
OpenAlex
W2055290156
Cited by
174
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
6.70
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Molecular and Cellular Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
thyroid-stimulating hormone, phospholipase C, cyclic AMP, inositol phosphates, IP3, diacylglycerol, human thyroid, adenylate cyclase, forskolin, isoproterenol, carbachol
MeSH terms
Cyclic AMP, Enzyme Activation, Humans, Inositol Phosphates, Kinetics, Type C Phospholipases, Thyroid Gland, Thyrotropin, In Vitro Techniques

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