Entorhinal projections to the hippocampal CA1 region in the rat: an underestimated pathway
Abstract
The projections of the entorhinal cortex to CA1 in relation to the entorhinal-dentate projections were studied in the rat, using the anterograde transport of Phaseolus vulgaris leucoagglutinin. It was observed that the entorhinal cortex is heterogeneous with respect to the origin of these projections. Caudomedial portions of the entorhinal cortex mainly distribute fibers to the fascia dentata, whereas only a minor projection reaches CA1. Progressively more rostral and lateral parts of the entorhinal cortex project more strongly to CA1, at the expense of the number of fibers that terminate in the fascia dentata. The rostrolateral part of the entorhinal cortex, adjacent to the olfactory cortex and the amygdaloid complex, projects only to CA1.
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Tau pathology spreads from transgene-expressing medial entorhinal cortex neurons to neurons without detectable transgene expression in downstream synaptically connected regions, including dentate gyrus, CA1, CA2/3, and cingulate cortex.
“Tau pathology progresses from EC transgene-expressing neurons to neurons without detectable transgene expression, first to EC neighboring cells, followed by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, CA fields of the hippocampus, and cingulate cortex.”
From Propagation of Tau Pathology in a Model of Early Alzheimer's Disease (2012) · cites this paper as Witter et al., 1988
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References 17 · Cited by 212
- Authors
- Witter, M. P., Griffioen, A. W., Jorritsma-Byham, B., & Krijnen, J. L. M.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Witter, Menno P.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1988-02
- Volume
- 85
- Issue
- 2
- Pages
- 193-198
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W1978294077
- Cited by
- 212
- References
- 17
- Citations by year
- 2026: 3 · 2023: 5 · 2022: 4 · 2021: 6 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- entorhinal cortex, hippocampal CA1, dentate gyrus, olfactory cortex, amygdala, anterograde tracing, leucoagglutinin
- MeSH terms
- Animals, Cerebral Cortex, Female, Hippocampus, Neural Pathways, Phytohemagglutinins, Rats, Inbred Strains, Rats
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