Relevance of the quantification of apolipoprotein E in the cerebrospinal fluid in Alzheimer's disease
Abstract
Apolipoprotein E (Apo E), one of the major structural and functional apolipoproteins, has recently been implicated in the pathogenesis of Alzheimer's disease (AD). Several studies revealed that Apo E4 isoform is associated with the pathogenic process in AD. A significant reduction of cerebrospinal fluid (CSF) Apo E level in AD patients has been reported in two studies. To further investigate the physiopathological significance of such a variation of Apo E concentration in the CSF, we performed a quantification of Apo E by an enzyme linked immunosorbent assay (ELISA). There were no significant differences in CSF Apo E level between AD cases and control subjects or patients suffering from other neurological diseases. Gender, age and Apo E phenotype explained none of CSF Apo E concentration variability.
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Previous studies of CSF apoE levels in humans provided no clear consensus on whether apoE protein levels are associated with AD.
“Previous studies of CSF apoE levels in humans provided no clear consensus on this question (Landen et al., 1996a; Lefranc et al., 1996; Lehtimaki et al., 1995; Lindh et al., 1997; Mulder et al., 1998; Sihlbom et al., 2008).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Lefranc et al., 1996
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The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
ApoE expression across the CNS: Who, What, Where, When, and How (much)?
Nolt, G. L., Lucido, C. C., Smith, L. M., & Johnson, L. A. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00028-x · Cited by 2 · see citing works
- Authors
- Lefranc, D., Vermersch, P., Dallongeville, J., Daems-Monpeurt, C., Petit, H., & Delacourte, A.
- Affiliations
- Inserm (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Corresponding author
- Delacourte, André
- ORCID
- Vermersch, Patrick
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 212
- Issue
- 2
- Pages
- 91-94
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2027326755
- Cited by
- 47
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 2 · 2020: 2 · 2017: 1 · 2015: 3 · 2012: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, cerebrospinal fluid, Alzheimer's disease, APOE ε4, apolipoprotein E phenotype, biomarkers, pathogenesis
- MeSH terms
- Aged, Alleles, Alzheimer Disease, Apolipoproteins E, Female, Humans, Male, Middle Aged, Sex Factors
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