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Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn
Abstract
We have studied the effects of intrathecal morphine on the responses of 38 dorsal horn neurones in the intact rat under halothane anaesthesia to A and C fibre electrical stimulation and to natural stimuli applied to their receptive fields. Morphine selectively reduced the C fibre and pinch evoked activity in a dose-dependent naloxone-reversible manner with an ED50 of 7 nmoles. The 'wind-up' of neurones to repetitive stimulation was little altered except with the highest doses (50-150 nmoles) tested. By contrast, the A fibre evoked responses of the neurones were only slightly reduced by morphine and both the tactile responses and receptive field size to innocuous stimuli enhanced for certain cells. The results are discussed in relation to the spinal actions of opiates and their clinical applications.
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Citations
Cited by
Mechanisms of hyperalgesian and morphine tolerance: a current view of their possible interactions
Mao, J., Price, D. D., & Mayer, D. J. (1995) · Pain · doi:10.1016/0304-3959(95)00073-2 · Cited by 818
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Dickenson, A. H., & Sullivan, A. F. (1987) · Pain · doi:10.1016/0304-3959(87)90023-6 · Cited by 536
Self-citationKCNQ/M Currents in Sensory Neurons: Significance for Pain Therapy
Passmore, G. M., Selyanko, A. A., Mistry, M., Al-Qatari, M., Marsh, S. J., Matthews, E. A., Dickenson, A. H., Brown, T. A., Burbidge, S. A., Main, M., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07227.2003 · Cited by 366
Self-citationPreemptive analgesia I: physiological pathways and pharmacological modalities
Kelly, D. J., Ahmad, M., & Brull, S. J. (2001) · Canadian Journal of Anesthesia/Journal canadien d'anesthésie · doi:10.1007/bf03016591 · Cited by 340
Metadata
- Authors
- Dickenson, A. H., & Sullivan, A. F.
- Venue
- Pain
- Published
- 1986-02
- Volume
- 24
- Issue
- 2
- Pages
- 211-222
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2088213907
- Cited by
- 270
- References
- 0
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dickenson, A. H., & Sullivan, A. F. (1986). Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain. https://doi.org/10.1016/0304-3959(86)90044-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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