The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF
Abstract
Transcutaneous nerve stimulation (TENS) treatment was given for 30 min to 37 patients divided into 3 groups of 10 patients and 1 group of 7 patients. Two groups received low-frequency (2 Hz) and the other 2 groups high-frequency (100 Hz) stimulation. A diagnostic lumbar cerebrospinal fluid (CSF) sample was obtained immediately before and after stimulation. The CSF samples were subjected to analysis of immunoreactive (ir) opioid peptides, Met-enkephalin-Arg-Phe (MEAP) from preproenkephalin and dynorphin A (Dyn A) from preprodynorphin, respectively. Low frequency TENS applied on the hand and the leg resulted in a marked increase (367%, P less than 0.05) of ir-MEAP but not ir-Dyn A, whereas high-frequency (100 Hz) TENS produced a 49% increase in ir-Dyn A (P less than 0.01) but not ir-MEAP. This is the first report in humans that 2 Hz and 100 Hz peripheral stimulation induces differential release of peptides from preproenkephalin and preprodynorphin, respectively.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone
Mayer, D. J., Price, D. D., & Rafii, A. (1977) · Brain Research · doi:10.1016/0006-8993(77)90161-5 · Cited by 759
Neurochemical Basis of Acupuncture Analgesia
Han, J. S., & Terenius, L. (1982) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.22.040182.001205 · Cited by 593
Self-citationIncreased Cerebrospinal Fluid Levels of Endorphins after Electro‐Acupuncture
Sjölund, B., Terenius, L., & Eriksson, M. (1977) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1977.tb05964.x · Cited by 464
Self-citationClement-Jones, V., Tomlin, S., Rees, L., Mcloughlin, L., Besser, G. M., & Wen, H. L. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92106-6 · Cited by 388
The influence of naloxone on analgesia produced by peripheral conditioning stimulation
Sjölund, B. H., & Eriksson, M. B. E. (1979) · Brain Research · doi:10.1016/0006-8993(79)90629-2 · Cited by 328
CLEMENTJONES, V (1979) · The Lancet · doi:10.1016/s0140-6736(79)90401-x · Cited by 214
Weber, E., Esch, F. S., Böhlen, P., Paterson, S., Corbett, A. D., McKnight, A. T., Kosterlitz, H. W., Barchas, J. D., & Evans, C. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.23.7362 · Cited by 122
Analgesia induced by intrathecal injection of dynorphin B in the rat
Han, J., Xie, G.-X., & D, A. G. M. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90612-x · Cited by 51
Self-citationOpioid-like activity in the cerebrospinal fluid of pain patients treated by electroacupuncture
Ho, W. K. K., & Wen, H. L. (1989) · Neuropharmacology · doi:10.1016/0028-3908(89)90196-2 · Cited by 47
Cited by
Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies
Han, J.-S. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00006-1 · Cited by 1,084
Self-citationAcupuncture analgesia: Areas of consensus and controversy
Han, J.-S. (2011) · Pain · doi:10.1016/j.pain.2010.10.012 · Cited by 294
Self-citationReview of recent advances in peripheral nerve stimulation (PNS)
Chakravarthy, K., Nava, A., Christo, P. J., & Williams, K. (2016) · Current Pain and Headache Reports · doi:10.1007/s11916-016-0590-8 · Cited by 136
Metadata
- Authors
- Han, J. S., Chen, X. H., Sun, S. L., Xu, X. J., Yuan, Y., Yan, S. C., Hao, J. X., & Terenius, L.
- Venue
- Pain
- Published
- 1991-12
- Volume
- 47
- Issue
- 3
- Pages
- 295-298
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2035228140
- Cited by
- 448
- References
- 9
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. https://app.cochat.ai/papers/10.1016/0304-3959(91)90218-m
- The paper
- Han, J. S., Chen, X. H., Sun, S. L., Xu, X. J., Yuan, Y., Yan, S. C., Hao, J. X., & Terenius, L. (1991). Effect of low- and high-frequency TENS on Met-enkephalin-Arg-Phe and dynorphin A immunoreactivity in human lumbar CSF. Pain. https://doi.org/10.1016/0304-3959(91)90218-m
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
