The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo
Abstract
Pain and sensory thresholds were examined before and after intravenous administration of ketamine (0.15 mg/kg), morphine (0.075 mg/kg) or saline in 8 patients with post-herpetic neuralgia. A randomized, double-blind, cross-over study design was used. Post-herpetic neuralgia was associated with impaired sensory function, as shown by reduced tactile and warm sensation in the affected compared with the contralateral non-affected skin area. Neither ketamine nor morphine changed significantly the thresholds for warm, cold, heat pain or tactile sensation. However, ketamine normalized abnormal heat pain sensations in 4 patients, probably due to a central effect. Ketamine, but not morphine, produced significant relief of pain. Pain evoked by non-noxious stimulation of the skin (allodynia) was significantly inhibited by ketamine as well as by morphine. Wind-up-like pain (i.e., pain evoked by repeatedly pricking the affected skin area) was significantly inhibited by ketamine, but significantly aggravated by morphine. Side effects were observed in all the 8 patients after injection of ketamine and in 6 patients after injection of morphine. The present results support the hypothesis that the N-methyl-D-aspartic acid (NMDA) receptors are involved in the control of post-herpetic neuralgia including allodynia and wind-up-like pain. The NMDA receptors also may play a role in the modulation of thermal perception.
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Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90161-h · Cited by 1,966 · cited 2×
“Long-lasting hyperexcitability in nociceptive neurons initiated by increased activity in primary afferents seems to play an important role in the pathogenesis of nerve injury pain (for review see Coderre et al. 1993).”
BackgroundGhoneim (1985) · doi:10.1097/00004714-198504000-00003 · Cited by 196
Cited by
Development and validation of the Neuropathic Pain Symptom Inventory
Bouhassira, D., Attal, N., Fermanian, J., Alchaar, H., Gautron, M., Masquelier, E., Rostaing, S., Lanteri-Minet, M., Collin, E., Grisart, J., et al. (2004) · Pain · doi:10.1016/j.pain.2003.12.024 · Cited by 1,329
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260
Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
Jensen, T. S., & Finnerup, N. B. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70102-4 · Cited by 976
Staud, R., Vierck, C. J., Cannon, R. L., Mauderli, A. P., & Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(00)00432-2 · Cited by 774
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Metadata
- Authors
- Eide, P. K., Jørum, E., Stubhaug, A., Bremnes, J., & Breivik, H.
- Venue
- Pain
- Published
- 1994-09
- Volume
- 58
- Issue
- 3
- Pages
- 347-354
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W18184263
- Cited by
- 490
- References
- 2
- FWCI
- 11.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo. https://app.cochat.ai/papers/10.1016/0304-3959(94)90129-5
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- Eide, P. K., Jørum, E., Stubhaug, A., Bremnes, J., & Breivik, H. (1994). Relief of post-herpetic neuralgia with the Symbol receptor antagonist ketamine: A double-blind, cross-over comparison with morphine and placebo. Pain. https://doi.org/10.1016/0304-3959(94)90129-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
