Comparative efficacy of albendazole against Fasciola hepatica in sheep and calves: Relationship to serum drug metabolites levels
Abstract
Calves were given albendazole (ABZ) daily in feed at levels of 0,3 or 5 mg kg-1 day-1. None of the ABZ treatment levels was significantly effective in reducing Fasciola hepatica burdens. A dose rate of 5 mg kd-1 day-1 did significantly reduce the fecal egg count. Measurements of serum drug levels from calves following a single dose of ABZ showed ABZ levels to be low, but sulfoxide and sulfone metabolites of ABZ were present in (significant) larger quantities. The total available sulfoxide present in calves, however, was much lower than in sheep receiving the same dose of ABZ. Measurements of serum metabolite levels from sheep and calves which were given daily low-level doses of ABZ also indicated that the serum sulfoxide levels of calves were much lower than those of sheep receiving the same ABZ dose. These results indicated that ABZ is not an effective prophylactic treatment for bovine fascioliasis and the differences in efficacy between sheep and cattle correlated with the differences in serum metabolite levels.
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Efficacy of albendazole was first documented in the 1970s-1980s against fascioliasis in animals, including cattle and sheep.
“The efficacy of albendazole was first documented in the 1970s-1980s against fascioliasis in animals, including cattle and sheep [1,254,255]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [255]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
- Authors
- Fetterer, R., Rew, R. S., & Knight, R.
- Affiliations
- United States Department of Agriculture (US)
- Venue
- Veterinary Parasitology
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 11
- Issue
- 4
- Pages
- 309-316
- ISSN
- 0304-4017 (ISSN-L)
- OpenAlex
- W1966619216
- Cited by
- 24
- References
- 0
- Citations by year
- 2026: 1 · 2021: 1 · 2017: 1
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Veterinary Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Keywords
- albendazole, Fasciola hepatica, bovine fasciolosis, sheep, calves, sulfoxide metabolites, sulfone metabolite, fecal egg count, anthelmintic efficacy, prophylaxis, species differences in drug response
- MeSH terms
- Animals, Anthelmintics, Benzimidazoles, Biotransformation, Cattle, Cattle Diseases, Fasciola hepatica, Fascioliasis, Female, Kinetics, Male, Sheep, Sheep Diseases, Albendazole
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