CoChat
Sign Up
Cited by 233Deep Brain Stimulation and Movement DisordersNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

The organization of midbrain projections to the striatum in the primate: Sensorimotor-related striatum versus ventral striatum

Open access
Lynd-Balta, E., Haber, S.N.·1994·Neuroscience
DOI 10.1016/0306-4522(94)90182-1
Open this paper in CoChat — free account

Abstract

In order to examine the organization of nigrostriatal projections in the primate, the retrograde tracers Lucifer Yellow conjugated to dextran amines and horseradish peroxidase conjugated to wheatgerm agglutinin were injected into different regions of the dorsolateral and ventral striatum. Based on the topography of cortical inputs to the striatum, the dorsolateral striatum is associated with the motor system, and the ventral striatum is related to the limbic system. Our results indicate that although midbrain neurons projecting to the ventral and dorsolateral striatum are mostly separate, there are neurons projecting to these different striatal territories that overlap in the medial substantia nigra. The dopaminergic neurons of the ventral mesencephalon can be subdivided into dorsal and ventral tiers that include the cells of the ventral tegmental area, the substantia nigra pars compacta, and the retrorubral area. Neurons projecting to the ventral striatum are found in both the dorsal and ventral tiers. A large number of neurons occupying the medial densocellular zone of the ventral tier are labeled following injections into different regions of the ventral striatum. Neurons projecting to the sensorimotor-related striatum are derived almost exclusively from the ventral tier. Many of these neurons are located very ventrally in the substantia nigra, where clusters of neurons invade the pars reticulata. In addition, labeled neurons are found throughout the mediolateral extent of the densocellular zone of the pars compacta. Notably, neurons are labeled in the medial densocellular zone following injections into the dorsolateral and ventral striatum. Mesencephalic neurons projecting to different striatal territories are distinct in that dorsal tier neurons mainly innervate the ventral striatum, whereas the ventral columns of neurons in the ventral tier innervate the sensorimotor-related striatum. Thus, the dopaminergic regulation of the sensorimotor-related striatum and the ventral striatum may be different. However, a subgroup of dopaminergic neurons in the medial densocellular zone projects to both striatal territories. Such divergent projections may allow the substantia nigra to serve as a link, connecting different striatal territories, via their connections with the substantia nigra.

Overview

Integrity signals

Registry

Crossref · 10.1016/0306-4522(94)90182-1

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 3

  1. Lynd-Balta, 1992, Organization of dopaminergic striatal projections in relation to peptidergic innervation of the substantia nigra in primate, Soc. Neurosci. Abstr., 18, 306
  2. Nagamoto, 1992, Distribution of dopamine D2 receptors in subpopulations of primate midbrain dopaminergic neurons, Soc. Neurosci. Abstr., 18, 660
  3. Szabo, 1979, Cellular and synaptic organization of basal ganglia, Appl. Neurophysiol., 42, 9

Cited by

Sorted by citations

See all 233

Related

See all

Metadata

Authors
Lynd-Balta, E., & Haber, S. N.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Haber, S.N.
ORCID
Haber, S.N.
Venue
Neuroscience
Publisher
Elsevier BV
Published
1994-04
Volume
59
Issue
3
Pages
625-640
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/0306-4522(94)90182-1
OpenAlex
W2071189762
Cited by
233
References
60
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 8 · 2021: 7 · 2020: 7 · 2019: 9 · 2018: 4 · 2017: 11 · 2016: 11 · 2015: 4 · 2014: 14 · 2013: 6 · 2012: 12
FWCI
5.24
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS22511, R01NS022511)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nigrostriatal projection, midbrain, ventral striatum, dorsolateral striatum, substantia nigra, ventral tegmental area, substantia nigra pars compacta, dopaminergic neurons, limbic system, primates
MeSH terms
Animals, Axonal Transport, Corpus Striatum, Fluorescent Dyes, Horseradish Peroxidase, Isoquinolines, Limbic System, Macaca mulatta, Macaca nemestrina, Mesencephalon, Neurons, Putamen, Substantia Nigra, Wheat Germ Agglutinins, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review