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Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems
Open accessAbstract
Toxicity of the respiratory system is a common side effect and complication of anticancer therapy that can result in significant morbidity. The range of respiratory compromise can extend from acute lethal events to degrees of chronic pulmonary decompensation, manifesting years after the initial cancer therapy. This review examines the anatomic-histologic background of the lung and the normal functional anatomic unit. The pathophysiology of radiation and chemotherapy induced lung injury is discussed as well as the associated clinical syndromes. Radiation tolerance doses and volumes are assessed in addition to chemotherapy tolerance and risk factors and radiation-chemotherapy interactions. There are a variety of measurable endpoints for detection and screening. Because of the wide range of available quantitative tests, it would seem that the measurement of impaired lung function is possible. The development of staging systems for acute and late toxicity is discussed and a new staging system for Late Effects in Normal Tissues (LENT) is proposed.
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Cited by
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604
Brunelli, A., Charloux, A., Bolliger, C. T., Rocco, G., Sculier, J.-P., Varela, G., Licker, M., Ferguson, M. K., Faivre-Finn, C., Huber, R. M., et al. (2009) · European Respiratory Journal · doi:10.1183/09031936.00184308 · Cited by 955
Effects of radiation on normal tissue: consequences and mechanisms
Stone, H. B., Coleman, C. N., Anscher, M. S., & McBride, W. H. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01191-4 · Cited by 931
TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?
Martin, M., Lefaix, J.-L., & Delanian, S. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(00)00435-1 · Cited by 657
MARKS, L., YU, X., VUJASKOVIC, Z., SMALLJR, W., FOLZ, R., & ANSCHER, M. (2003) · Seminars in Radiation Oncology · doi:10.1016/s1053-4296(03)00034-1 · Cited by 364
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Metadata
- Authors
- McDonald, S., Rubin, P., Phillips, T. L., & Marks, L. B.
- Venue
- International Journal of Radiation Oncology*Biology*Physics
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 31
- Issue
- 5
- Pages
- 1187-1203
- ISSN
- 0360-3016 (ISSN-L)
- OpenAlex
- W2019822838
- Cited by
- 401
- References
- 0
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems. https://app.cochat.ai/papers/10.1016/0360-3016(94)00429-o
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- McDonald, S., Rubin, P., Phillips, T. L., & Marks, L. B. (1995). Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems. International Journal of Radiation Oncology*Biology*Physics. https://doi.org/10.1016/0360-3016(94)00429-o
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