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Administration of satiety factors and gustatory responsiveness in the nucleus tractus solitarius of the rat
Abstract
The administration of certain factors associated with postprandial satiety decreases gustatory responsiveness. We compared the effects of intravenous injections of glucose, insulin, pancreatic glucagon (PG), and cholecystokinin (CCK) on multiunit activity evoked from taste responsive neurons in the nucleus tractus solitarius of rats. Glucose, insulin, and PG reliably suppressed evoked responses to lingual application of 1.0M glucose, whereas responses that followed CCK remained unchanged. A common physiological consequence of glucose, insulin, and glucagon is increased glucose availability which may impact directly on gustatory neurons or indirectly through modifications in ventral forebrain or vagal afferent activity.
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“Third, in rodents, reward value as indicated in devaluation (satiety) studies involves reward processing even far peripherally in the first central relay, the nucleus of the solitary tract for taste (Giza and Scott, 1983, 1987; Giza et al., 1992), and the olfactory bulb for odour (Pager et al., 1972), making these complex systems, as reward and identity processing about taste and odour are”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Giza et al., 1992
Citations
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Metadata
- Authors
- Giza, B. K., Scott, T. R., & Vanderweele, D. A.
- Affiliations
- University of Delaware (US)
- Occidental College (US)
- Corresponding author
- Scott, Thomas R.
- ORCID
- Scott, Thomas R.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1992-04
- Volume
- 28
- Issue
- 4
- Pages
- 637-639
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2014281887
- Cited by
- 52
- References
- 10
- Citations by year
- 2025: 1 · 2022: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2015: 6 · 2014: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2r01dk030964-07)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-30964)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- satiety factor, nucleus tractus solitarius, taste neurons, glucose, insulin, pancreatic glucagon, cholecystokinin, postprandial satiety, multi-unit activity, vagal afferents
- MeSH terms
- Animals, Cholecystokinin, Female, Glucagon, Glucose, Hormones, Insulin, Medulla Oblongata, Satiety Response, Taste, Rats
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