Vitamin E attenuates the toxic effects of 6-hydroxydopamine on free radical scavenging systems in rat brain
Abstract
Rats were divided into the following four groups namely (a) sham-operated control, (b) 6-OHDA-treated, (c) sham-operated vitamin E-fed and (d) Vitamin E-fed treated with 6-OHDA. Total glutathione (GSH) and superoxide dismutase (SOD) were measured in brainstem (BS), striatum (ST), hippocampus, frontal cortex, and nucleus accumbens (N. Acc.). GSH and SOD levels were significantly decreased in all regions of 6-OHDA-treated rats compared to controls. Feeding of vitamin E resulted in a significant reduction of GSH in ST and N. Acc. but caused increases in SOD in BS, ST, and N. Acc. Pretreatment of rats with vitamin E caused significant attenuation of the effects of 6-OHDA on GSH and SOD in most of the brain regions. These results show that vitamin E can spare the scavenging systems from the injurious effects of 6-OHDA.
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Rectal gel application of Withania somnifera root extracts (500 microg/ml and 1000 mg/kg b.w.) exhibits mucorestorative and anti-inflammatory activities by reducing neutrophil infiltration, necrosis, and edema in TNBS-induced inflammatory bowel disease.
“Rectal gel application of WS root extracts (500 µg/ml and 1000 mg/kg b.w.) were documented to exhibit mucorestorative and anti-inflammatory activities by reducing neutrophil infiltration, necrosis, and edema in trinitrobenzene sulfonic acid (TNBS)-induced inflammatory bowel disease [265].”
From Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects (2021) · cites this paper as [265]
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References 29 · Cited by 120
- Authors
- Perumal, A. S., Gopal, V. B., Tordzro, W. K., Cooper, T. B., & Cadet, J. L.
- Affiliations
- New York State Psychiatric Institute (US)
- Corresponding author
- Perumal, A.S.
- ORCID
- Cooper, T.B.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 29
- Issue
- 5
- Pages
- 699-701
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W2058186282
- Cited by
- 120
- References
- 29
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 8
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- vitamin E, 6-hydroxydopamine, neurotoxicity, free radical scavenging, glutathione, superoxide dismutase, antioxidant defense, striatum, nucleus accumbens, brainstem, hippocampus, frontal cortex, neuroprotection
- MeSH terms
- Animals, Brain, Brain Chemistry, Glutathione, Male, Superoxide Dismutase, Vitamin E, Free Radical Scavengers, Oxidopamine, Rats, Sprague-Dawley, Rats
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