PAD1 encodes phenylacrylic acid decarboxylase which confers resistance to cinnamic acid in Saccharomyces cerevisiae
Abstract
The yeast enzyme phenylacrylic acid decarboxylase (PAD) confers resistance to phenylacrylic acids. Cinnamic acid (CA)-sensitive mutants lacking PAD activity were isolated and the PAD1 gene was cloned by phenotypic complementation. The nucleotide sequence of the smallest complementing fragment was determined. The predicted 242-amino-acid PAD polypeptide is 48.6% identical to the product of dedF of Escherichia coli. PAD activity and CA resistance, but not steady-state PAD1 mRNA levels, are influenced by mitochondrial genotype. PAD1 is a single-copy gene in the yeast genome and not essential for viability. The PAD1 locus was physically mapped to a position approx. 140 kb from the left end of chromosome IV.
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Production of phenolic off-flavours by Saccharomyces uvarum brewing strains is dependent on the presence of a functional allele of the PAD1/POF1 phenylacrylic acid decarboxylase gene.
“The production of phenolic off-flavours by Saccharomyces uvarum brewing strains is dependent on the presence of a functional allele of the PAD1/POF1 phenylacrylic acid decarboxylase gene (Meaden and Taylor 1991, Hwang 1992, Clausen et al. 1994, Shinohara et al. 2000).”
From Yeast and bacterial modulation of wine aroma and flavour (2005) · cites this paper as Clausen et al. 1994
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Yeast and bacterial modulation of wine aroma and flavour
SWIEGERS, J. H., BARTOWSKY, E. J., HENSCHKE, P. A., & PRETORIUS, I. S. (2005) · Australian Journal of Grape and Wine Research · doi:10.1111/j.1755-0238.2005.tb00285.x · Cited by 1,216 · see citing works
Filannino, P., Bai, Y., Di Cagno, R., Gobbetti, M., & Gänzle, M. G. (2015) · Food Microbiology · doi:10.1016/j.fm.2014.08.018 · Cited by 354 · see citing works
- Authors
- Clausen, M., Lamb, C. J., Megnet, R., & Doerner, P. W.
- Affiliations
- Carl von Ossietzky Universität Oldenburg (DE)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Doerner, Peter W.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 1994-05
- Volume
- 142
- Issue
- 1
- Pages
- 107-112
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W1964281642
- Cited by
- 155
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2021: 4 · 2020: 13 · 2019: 4 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 13 · 2013: 4 · 2012: 5
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Saccharomyces cerevisiae, mitochondrial genotype, gene cloning, physical mapping, chromosome IV
- MeSH terms
- Amino Acid Sequence, Base Sequence, Carboxy-Lyases, Cinnamates, DNA, Fungal, Drug Resistance, Microbial, Fungal Proteins, Molecular Sequence Data, Saccharomyces cerevisiae, Restriction Mapping
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