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Tris acetylacetonate aluminium(III) induces osmotic fragility and acanthocyte formation in suspended erythrocytes
Abstract
Tris acetylacetonate aluminium(III) (Al(acac)3), dissolved in water, is effective in producing osmotic fragility in suspended erythrocytes in the concentration range of 0.034-0.34 mmol/l. Water solutions of Tris maltolate aluminium(III) (Al(malt)3) and aluminium lactate (Al(lac)3) are also effective but the dose-response behavior is less pronounced. Moreover, only Al(acac)3 induces a prominent generation of acanthocytes. The stronger effects of Al(acac)3 on membrane stability are attributed to the greater solubility of this complex in the cell membrane.
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Erythrocyte osmotic fragility decreased or increased depending on the Al speciation and type of erythrocyte injury.
“Erythrocyte osmotic fragility decreased (Bazzoni et al., 2005) or increased (Zatta et al., 1989; Hernández et al., 2008; Al-Qayim et al., 2014; Oztürk and Ozdemir, 2015, Zhang et al., 2016; Cheng et al., 2018) depending on the Al speciation and type of erythrocyte injury.”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Zatta et al., 1989
Additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilization.
“The additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of the enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilization (Zatta et al., 1989; Perez et al., 2001; Bazzoni et al., 2005; Vittori et al.,”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Zatta et al., 1989
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Research works printed but not linked: 10
- Crapper McLachlan, 1986, Aluminium and Alzheimer's disease, Neurobiol. Aging, 7, 525, 10.1016/0197-4580(86)90102-8 · DOI
- Wisniewski, 1980, Aluminium chloride induces neurofibrillary changes in the developing rabbit: a chronic animal model, Ann. Neurol., 8, 471, 10.1002/ana.410080505 · DOI
- De Boni, 1976, Neurofibrillary degeneration induced by systemic aluminium, Acta Neuropathol. (Berl.), 35, 285
- Zatta, 1987, A neutral lipophilic compound of aluminium (III) as a cause of myocardial infarct in the rabbit, Toxicol. Lett., 39, 185, 10.1016/0378-4274(87)90231-1 · DOI
- Gutteridge, 1986, Aluminum salts accelerate peroxidation of membrane lipids stimulated by iron salts, Biochim. Biophys. Acta, 835, 441, 10.1016/0005-2760(85)90113-4 · DOI
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- Finnegan, 1986, A neutral water-soluble aluminum complex of neurological interest, J. Am. Chem. Soc., 108, 5033, 10.1021/ja00276a069 · DOI
- Yung, 1946, Aluminum acetylacetonate, Inorg. Synth., 11, 25, 10.1002/9780470132333.ch9 · DOI
- Tapparo, 1988, n-Octanol/water partition coefficients of the acetylacetonate and maltolate complexes of Al(III), Cr(III), and Fe(III) and of aluminum lactate, J. Toxicol. Environm. Chem.
- Staurnes, 1984, Reduced carbonic anhydrase and Na-K-ATPase activity in gills of salmonids exposed to aluminium-containing acid water, Experientia, 40, 226, 10.1007/BF01963613 · DOI
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Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“The additional causes of anemia appear to be multi-factorial and include defective hemoglobin production due to inhibition of the enzymes of heme synthesis, altered erythrocyte membrane structure and fragility, shortening of red blood cell life span due to eryptotic and oncotic injuries, and inadequate iron utilizatio…”
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Metadata
- Authors
- Zatta, P., Perazzolo, M., & Corain, B.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Corain, Benedetto
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 45
- Issue
- 1
- Pages
- 15-21
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W1966538266
- Cited by
- 22
- References
- 0
- Citations by year
- 2019: 2 · 2012: 1
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- aluminum(III) complexes, osmotic fragility, erythrocytes, acanthocytes, erythrocyte membrane stability, aluminum toxicity, dose-response relationship
- MeSH terms
- Acanthocytes, Aluminum, Animals, Cell Membrane Permeability, Erythrocyte Membrane, Erythrocytes, Abnormal, Ketones, Microscopy, Electron, Scanning, Organometallic Compounds, Osmotic Fragility, Pentanones, Rabbits, Solubility
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