The role of the skin in the development of chemical respiratory hypersensitivity
Abstract
Certain chemicals are known to cause occupational respiratory allergy associated with symptoms of pulmonary distress, including asthma and rhinitis. While there is no doubt that inhalation represents an important route of exposure for the development of sensitization to the inducing allergen, there is evidence that effective sensitization of the respiratory tract may result also from dermal contact with the chemical. The mechanisms relevant to the stimulation of respiratory sensitization following cutaneous exposure to chemical allergens and implications for the prevention of occupational asthma are considered here.
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Chemicals known to cause respiratory tract sensitization include diisocyanates, acid anhydrides, some platinum salts, reactive dyes, glutaraldehyde, plicatic acid, and chroamine.
“Chemicals known to cause sensitization of the respiratory tract include diisocyanates, acid anhydrides, some platinum salts, reactive dyes, glutaraldehyde, plicatic acid, and chroamine.118-120”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [119]
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Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure
Kimber, I., & Dearman, R. J. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00299-8 · Cited by 96 · see citing works
Self-citation
- Authors
- Kimber, I.
- Affiliations
- Zeneca Central Toxicology Laboratory (GB)
- Corresponding author
- Kimber, I
- ORCID
- Kimber, I
- Venue
- Toxicology Letters
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 86
- Issue
- 2-3
- Pages
- 89-92
- ISSN
- 0378-4274 (ISSN-L)
- OpenAlex
- W1995835002
- Cited by
- 51
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology Letters (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- occupational asthma, occupational respiratory allergy, skin sensitization, dermal exposure, respiratory sensitization, rhinitis, allergen sensitization
- MeSH terms
- Administration, Cutaneous, Allergens, Animals, Dermatitis, Atopic, Environmental Pollutants, Humans, Occupational Diseases, Respiratory Hypersensitivity, Skin
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