The two-stage mechanism controlling cellular senescence and immortalization
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Dysfunctional telomeres are recognized as DNA double-strand breaks that impinge upon p53 and/or pRB tumor suppressor pathways, inducing p21 and p16 Ink4a to initiate replicative senescence.
“These results suggest that dysfunctional telomeres are recognized as DSBs that impinge upon p53 and/or pRB tumor suppressor pathways, to induce expression of their regulators p21 and p16 Ink4a to initiate replicative senescence24-26.”
From Telomere dysfunction and tumour suppression: the senescence connection (2008) · cites this paper as [24]
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References 15 · Cited by 383
- Authors
- Wright, W. E., & Shay, J. W.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Wright, Woodring E.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 1992-07
- Volume
- 27
- Issue
- 4
- Pages
- 383-389
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W1992430278
- Cited by
- 383
- References
- 15
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 5 · 2019: 11 · 2018: 9 · 2017: 17 · 2016: 2 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 18
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca050195-05)
- National Institute on Aging (AG07992, R01AG007992)
- National Cancer Institute (CA 50195)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- cellular senescence, cell immortalization, telomeres, shelterin, telomerase, telomerase reverse transcriptase, telomere protection, DNA damage response, telomere length regulation, embryonic stem cells, pluripotency, genome stability
- MeSH terms
- Aging, Antigens, Polyomavirus Transforming, Cell Division, Cell Survival, Cell Transformation, Viral, Cells, Cultured, Humans, Simian virus 40, Genes, p53, Genes, Retinoblastoma, Telomere
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