The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
A case for early surgery in native left-sided endocarditis complicated by heart failure: Results in 203 patients
Open accessAbstract
From January 1982 to December 1988, 203 consecutive patients were selected for early valve replacement (mean 10 days from time of admission) if they had clinical evidence of native valve endocarditis with 1) vegetations on echocardiography, 2) severe valvular lesions, and 3) heart failure. Surgery was performed within 7 days of admission in 56% of patients and was done urgently because of hemodynamic deterioration in 108 (53%). All vegetations were identified by echocardiography and confirmed macroscopically at surgery. One hundred ten patients had isolated aortic valve infection, 50 had isolated mitral valve infection (p less than 0.05 for aortic vs. mitral) and 43 had double-valve infection. Mean aortic cross-clamp time was 57, 38 and 67 min, respectively. Sixty-four patients (32%) had extensive infection involving the anulus or adjacent tissues, or both; such infection more frequently involved the aortic than the mitral valve (p less than 0.05). Thirty-eight patients (35%) with aortic valve infection had abscess formation compared with 1 patient (2%) with mitral valve infection (p less than 0.05). Only eight patients (4%) died in the hospital. There were seven patients (3%) with a periprosthetic leak and five patients (3%) with early prosthetic valve endocarditis. Long-term follow-up, available in 174 hospital survivors (89%), revealed 10 deaths and two new ring leaks at 38 +/- 22 months. In conclusion, among patients with endocarditis who need surgery for heart failure, aortic valve infection is more prevalent than mitral valve infection and is more often associated with extensive infection, including abscess formation.(ABSTRACT TRUNCATED AT 250 WORDS)
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“Extension of IE beyond the valve annulus predicts a higher mortality rate, more frequent development of heart failure, and more frequent need for cardiac surgery.284,297,298”
From Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association (2015) · cites this paper as [297]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Only aortic valve involvement and current IDU have been prospectively identified as independent risk factors for perivalvular abscess.297”
From Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association (2015) · cites this paper as [297]
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“The size of vegetations is not helpful for predicting perivalvular extension.297”
From Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association (2015) · cites this paper as [297]
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Metadata
- Authors
- Middlemost, S., Wisenbaugh, T., Meyerowitz, C., Teeger, S., Essop, R., Skoularigis, J., Cronje, S., & Sareli, P.
- Affiliations
- Chris Hani Baragwanath Hospital (ZA)
- Corresponding author
- Middlemost, Shirley
- ORCID
- Skoularigis, John
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1991-09
- Volume
- 18
- Issue
- 3
- Pages
- 663-667
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W1973206712
- Semantic Scholar
- 6e7a106bb3a5fc97be317fee64ddfbb1b5d8c2c6
- Cited by
- 141
- References
- 47
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 8 · 2012: 4
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Keywords
- infective endocarditis, native valve endocarditis, left-sided endocarditis, heart failure, aortic valve infection, mitral valve infection, periprosthetic leak, prosthetic valve endocarditis, timing of surgery, echocardiographic vegetation
- MeSH terms
- Adult, Aortic Valve, Endocarditis, Bacterial, Female, Heart Failure, Heart Valve Prosthesis, Humans, Male, Mitral Valve, Postoperative Complications, Retrospective Studies, Risk Factors, Time Factors, Prevalence
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