The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Coronary circulation in dogs with an experimental decrease in aortic compliance
Open accessAbstract
Objectives This study was designed to investigate the effects of decreased aortic compliance on the coronary circulation.Background A decrease in aortic compliance due to arteriosclerosis is observed in patients with coronary artery disease. However, the effects of decreased aortic compliance on the coronary circulation have not yet been investigated sufficiently.Methods Hemodynamics, subendocardial electrocardiogram (ECG), myocardial segmental length and myocardial blood flow were investigated in six dogs with aortic bandaging (bandaged group) and five dogs with a sham operation (control group) at rest and during pacing 4 weeks after surgery.Results Aortic compliance in the bandaged group was less than that in the control group (0.24 +/- 0.20 vs. 0.50 +/- 0.22 ml/mm Hg, p < 0.05). Pulse pressure and the tension-time index were significantly greater in the bandaged group than in the control group, but systemic vascular resistance was not altered significantly. The subendocardial/subepicardial flow ratio was lower in the bandaged group than in the control group (0.95 +/- 0.31 vs. 1.57 +/- 0.26, p < 0.05). In the region supplied by the left circumflex artery with a stenosis that was adjusted to eliminate reactive hyperemia, rapid atrial pacing (heart rate 200 beats/min) further decreased endocardial flow and the endocardial/epicardial flow ratio in the bandaged group. Moreover, both the reduction of segmental shortening and the ST elevation on the subendocardial ECG in the left circumflex-supplied region during pacing were greater in the bandaged group.Conclusions These results indicate that decreased aortic compliance greatly increases the risk of subendocardial ischemia in the presence of coronary stenosis.
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“Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”
From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [7]
In the citing paper
“Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”
From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [7]
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Metadata
- Authors
- Watanabe, H., Ohtsuka, S., Kakihana, M., & Sugishita, Y.
- Affiliations
- University of Tsukuba (JP)
- Corresponding author
- Watanabe, Hideki
- ORCID
- Watanabe, Hideki
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 21
- Issue
- 6
- Pages
- 1497-1506
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2028105762
- Cited by
- 278
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 6 · 2013: 10 · 2012: 13
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- aortic compliance, coronary circulation, subendocardial ischemia, coronary artery stenosis, aortic banding, myocardial blood flow, left circumflex artery, atrial pacing, ST-segment elevation, pulse pressure, tension-time index, arteriosclerosis, coronary artery disease
- MeSH terms
- Animals, Aorta, Compliance, Coronary Circulation, Coronary Disease, Dogs, Electrocardiography, Hemodynamics, Regional Blood Flow, Myocardial Ischemia
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