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Alcohol-related seizures, part I: Pathophysiology, differential diagnosis, and evaluation
Open accessAbstract
Alcoholism may be society's most devastating problem short of war and malnutrition. Perhaps the most complex and perplexing medical complication of alcoholism is alcohol-related seizures. This article is a collective review designed to provide emergency physicians with an overview of the topic that is pertinent to their clinical practice. Part 1 addresses the pathophysiology, differential diagnosis, and evaluation of alcohol-related seizures. Part 2 will concentrate on the clinical presentation, management, and disposition. In addition, a classification of alcohol-related seizures will be proposed.
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“Other theories postulate cerebral atrophy, cerebrovascular infarctions, lesions, traumas, neuroplasticity and chronic electrolyte imbalances as leading to the onset of seizures 233, 234, 235.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [234]
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References 124 · Cited by 46
Research works printed but not linked: 11
- Rathlev, 1992, Etiology of alcohol withdrawal seizures and their occurrence in relation to the decreased availability of alcohol [abstract], Ann Emerg Med., 21, 663
- Favazza, 1983, Alcoholism, Am Fam Physician, 27, 274
- Victor, 1988, Alcohol-withdrawal seizures: an overview [abstract], Epilepsia, 29, 497
- Ng, 1989, Alcohol consumption and withdrawal in new-onset seizures (reply), N Engl J Med., 320, 597
- Lovinger, 1988, Intoxicating concentrations of ethanol inhibit NMDA-induced ionic currents in isolated mammalian neurons, Epilepsia, 24, 497
- Morrow, 1988, Chronic ethanol administration alters Gaba-aminobutyric acid, pento barbital and ethanol-mediated 36C1-uptake in cerebral cortical synaptoneurosomes, J Pharmacol Exp Ther., 246, 442, 10.1016/S0022-3565(25)20996-X · DOI
- Lieber, 1981, The effects of alcohol and alcoholic liver disease on the endocrine system and intermediary metabolism, Major Prob Intern Med., 3, 65
- Larremore, 1984, Alcohol-induced ketoacidosis and hypoglycemia, Top Emerg Med., 6, 48
- Rodibaugh, 1987, Choosing an imaging technique, Emerg Med., 26
- Vossler, 1988, Usefulness of EEG in the management of alcohol withdrawal seizures [abstract], Epilepsia, 29, 494
- Hauser, 1982, Electroencephalographic findings in patients with ethanol withdrawal seizures [abstract], Electroencephalogr Clin Neurophysiol, 152, 64
Metadata
- Authors
- Freedland, E. S., & McMicken, D. B.
- Affiliations
- Boston University (US)
- Corresponding author
- Freedland, Eric S.
- Venue
- The Journal of Emergency Medicine
- Publisher
- Elsevier BV
- Published
- 1993-07
- Volume
- 11
- Issue
- 4
- Pages
- 463-473
- ISSN
- 0736-4679 (ISSN-L)
- OpenAlex
- W2075323393
- Cited by
- 46
- References
- 124
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2019: 1 · 2017: 2 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Emergency Medicine (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- alcohol-related seizures, alcoholism, pathophysiology, differential diagnosis, seizure evaluation, emergency medicine
- MeSH terms
- Ethanol, Alcoholism, Electroencephalography, Humans, Magnetic Resonance Imaging, Seizures, Substance Withdrawal Syndrome, Tomography, X-Ray Computed
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