Regional brain contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats
Abstract
The contents of dopamine (DA), serotonin (5-HT) and their primary acid metabolites were assayed in ten brain regions of the selectively bred high-alcohol drinking (HAD) and low-alcohol drinking (LAD) lines of rats. Compared with the LAD line, the contents of 5-HT and/or 5-hydroxyindoleacetic acid were approximately 10-20% (p less than 0.05) lower in several brain regions of the HAD line (cerebral cortex, striatum, nucleus accumbens, septal nuclei, hippocampus and hypothalamus). The levels of DA, 3,4-dihydroxyphenylacetic acid and homovanillic acid were also 10-20% lower in the nucleus accumbens and anterior striatum (p less than 0.05) of the HAD animals. These data are in agreement with previous findings that comparatively lower levels in 5-HT and DA systems are associated with high-alcohol drinking in rodents and support the involvement of certain 5-HT and DA pathways in the mediation of alcohol drinking behavior.
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Alcohol-naïve mice or rats selectively bred to prefer ethanol display decreased basal dopamine levels in the nucleus accumbens, and alcohol preference in these animals is reversed by direct dopamine receptor activation.
“Indeed, alcohol-naïve mice (George et al., 1995) or rats (Gongwer et al., 1989; Quintanilla et al., 2007) selectively bred to prefer ethanol display decreased basal dopamine levels in the nucleus accumbens, and alcohol preference in these animals is reversed by direct dopamine receptor activation (George et al., 1995).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Gongwer et al., 1989
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References 26 · Cited by 179
- Authors
- Gongwer, M. A., Murphy, J. M., McBride, W. J., Lumeng, L., & Li, T.-K.
- Affiliations
- Regenstrief Institute (US)
- Corresponding author
- McBride, W.J.
- ORCID
- McBride, W.J.
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 1989-07
- Volume
- 6
- Issue
- 4
- Pages
- 317-320
- ISSN
- 0741-8329 (ISSN-L)
- OpenAlex
- W2013032254
- Cited by
- 179
- References
- 26
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 6 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA 03243, AA-07611, AA-07462)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- serotonin, dopamine, alcohol drinking behavior, high-alcohol-drinking rats, 5-hydroxyindoleacetic acid, DOPAC, homovanillic acid, brain neurotransmitter levels, nucleus accumbens, striatum, alcohol preference
- MeSH terms
- Alcohol Drinking, Animals, Brain Chemistry, Breeding, Dopamine, Homovanillic Acid, Hydroxyindoleacetic Acid, Male, Serotonin, Tissue Distribution, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines, Rats
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