Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
Open accessAbstract
The effects of dronabinol on appetite and weight were evaluated in 139 patients with AIDS-related anorexia and > or = 2.3 kg weight loss in a multi-institutional study. Patients were randomized to receive 2.5 mg dronabinol twice daily or placebo. Patients rated appetite, mood, and nausea by using a 100-mm visual analogue scale 3 days weekly. Efficacy was evaluable in 88 patients. Dronabinol was associated with increased appetite above baseline (38% vs 8% for placebo, P = 0.015), improvement in mood (10% vs -2%, P = 0.06), and decreased nausea (20% vs 7%; P = 0.05). Weight was stable in dronabinol patients, while placebo recipients had a mean loss of 0.4 kg (P = 0.14). Of the dronabinol patients, 22% gained > or = 2 kg, compared with 10.5% of placebo recipients (P = 0.11). Side effects were mostly mild to moderate in severity (euphoria, dizziness, thinking abnormalities); there was no difference in discontinued therapy between dronabinol (8.3%) and placebo (4.5%) recipients. Dronabinol was found to be safe and effective for anorexia associated with weight loss in patients with AIDS.
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Dronabinol is used to counteract AIDS-related wasting and promote appetite in patients suffering from AIDS-related anorexia.
“Dronabinol (Marinol®) is used to counteract AIDS-related wasting and promote appetite in patients suffering from AIDS-related anorexia.139”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [139]
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References 7 · Cited by 504
Research works printed but not linked: 2
- [1]1. Centers for Disease Control. Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. MMWR 1987;36:3S–15S.
- [2]2. Hellerstein MK. Pathophysiology of lean body wasting and nutrient unresponsiveness in HIV/ AIDS: "therapeutic implications. Nutr HIV/AIDS 1992;1:17-25.
- Authors
- Beal, J. E., Olson, R., Laubenstein, L., Morales, J. O., Bellman, P., Yangco, B., Lefkowitz, L., Plasse, T. F., & Shepard, K. V.
- Affiliations
- St. John Medical Center (US)
- NYU Langone Health (US)
- St. Joseph's Hospital (US)
- Vanderbilt University Medical Center (US)
- Venue
- Journal of Pain and Symptom Management
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 10
- Issue
- 2
- Pages
- 89-97
- ISSN
- 0885-3924 (ISSN-L)
- OpenAlex
- W2068743551
- Cited by
- 504
- References
- 7
- Citations by year
- 2026: 12 · 2025: 9 · 2024: 14 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 14 · 2019: 18 · 2018: 27 · 2017: 19 · 2016: 14 · 2015: 21 · 2014: 12 · 2013: 11 · 2012: 11
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Pain and Symptom Management (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- dronabinol, weight loss, appetite, mood, nausea, weight gain, cannabinoid therapy, drug safety, adverse effects
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Anorexia, Double-Blind Method, Female, Humans, Male, Middle Aged, Dronabinol, Weight Loss
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