Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 14Pharmacological Effects and Toxicity StudiesEpilepsy research and treatmentAnesthesia and Neurotoxicity Research

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Effects of sodium valproate on development and social behaviour in the Mongolian gerbil

Chapman, Jan B., Cutler, Margaret G.·1989·Neurotoxicology and Teratology
DOI 10.1016/0892-0362(89)90058-5
Open this paper in CoChat — free account

Abstract

Sodium valproate is an anticonvulsant widely prescribed because of its broad spectrum of activity. While acute toxicity from high doses is well recognized, there have been few animal studies of its chronic toxicity at therapeutic dose levels. Sodium valproate given continuously in drinking fluid (600 mg/l) throughout pregnancy and lactation to breeding gerbils caused developmental delay of the self-righting reflex in their pups. Dams ingested 97 mg/kg daily during gestation and 151 mg/kg on average during lactation, a dose in the lower range of anticonvulsant effectiveness. Reproductive performance, birth weights and subsequent growth of the pups remained normal, as did brain weights in adulthood. Drug-treated offspring, continuing to receive valproate as drinking fluid after weaning (600 mg/l; 82 to 111 mg/kg) showed negligible behavioural alteration at 6 weeks of age as assessed by ethological procedures, although behavioural change did occur at 20 weeks in the female animals. These females were characterised by significant enhancement of exploration and scanning during dyadic encounters in an unfamiliar cage, and showed a concomitant reduction of other nonsocial activities. Short-term administration of this dose of the drug did not affect behaviour. These results suggest an increased reactivity to the environment which becomes evident only after long-term treatment with valproate and to which female animals are more susceptible than males. These findings of developmental delay and of modifications to behaviour later in life points to the need for more detailed clinical assessments of the effects of valproate in human patients.

Overview

Integrity signals

Registry

Crossref · 10.1016/0892-0362(89)90058-5

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 6

  1. Diaz, 1978, Chronic administration of dipropylacetate early in life: effects on brain development and behaviour, Ann. Neurol., 4, 198
  2. Eymard, 1972, Etude pharmacologique complementaire du di-n-propylacetamide ou depamide, Therapie, 27, 11
  3. Misslin, 1972, Effets du di-n-propylacetate sur l'activite spontanee de la souris, C R Acad. Sci. (Paris), 275, 1279
  4. Simiand, 1983, Antiaggressive, anxiolytic and antianoxic effects of valproate in animals, Br. J. Clin. Pract., 155
  5. Suchestron, 1979, Fetal malformations in valproate sodium treated CD-1 mice, Teratology, 19, 49A
  6. Will, 1972, Effets du di-n-propylacetate sur diverses reactions conditionees chez le rat, C R Acad. Sci. (Paris), 275, 2921

Cited by

See all 14

Related

See all

Metadata

Authors
Chapman, J. B., & Cutler, M. G.
Affiliations
City of Glasgow College (GB)
Venue
Neurotoxicology and Teratology
Publisher
Elsevier BV
Published
1989-03
Volume
11
Issue
2
Pages
193-198
ISSN
0892-0362 (ISSN-L)
DOI
10.1016/0892-0362(89)90058-5
OpenAlex
W2075882758
Cited by
14
References
41
Citations by year
2015: 1 · 2014: 1 · 2013: 1
FWCI
2.02
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neurotoxicology and Teratology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords
valproic acid, developmental delay, social behavior, Mongolian gerbil, prenatal drug exposure, pregnancy and lactation, chronic toxicity, sex differences, exploratory behavior
MeSH terms
Administration, Oral, Aggression, Aging, Animals, Behavior, Animal, Brain, Drug Administration Schedule, Escape Reaction, Exploratory Behavior, Female, Gerbillinae, Male, Reference Values, Reproduction, Sex Factors, Valproic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.