Distribution of mRNA for the calmodulin-sensitive adenylate cyclase in rat brain: Expression in areas associated with learning and memory
Abstract
The Drosophila learning mutant, rutabaga, is deficient in the calmodulin-sensitive adenylate cyclase, and studies of associative learning in Aplysia have implicated this enzyme in neuroplasticity. Therefore, the distribution of mRNA encoding the calmodulin-sensitive adenylate cyclase in rat brain was examined by in situ hybridization. mRNA for this enzyme is expressed in specific areas of brain that have been implicated in learning and memory, including the neocortex, the hippocampus, and the olfactory system. The presence of mRNA for this enzyme in the pyramidal and granule cells of the hippocampal formation provides evidence that it is found in neurons. These data are consistent with the proposal that the calmodulin-sensitive adenylate cyclase plays an important role in learning and memory.
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AC1 is neurospecific and expressed in the dentate gyrus and the pyramidal cells in CA1, CA2, and CA3 layers of the hippocampus.
“AC1 is neurospecific and expressed in the dentate gyrus and the pyramidal cells in CA1, CA2, and CA3 layers of the hippocampus (Xia et al., 1991(Xia et al., , 1993)).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Xia et al., 1991
Neurons of the hippocampus express Ca2+-stimulated adenylyl cyclases.
“Because neurons of the hippocampus express Ca 2ϩ -stimulated adenylyl cyclases (Xia et al., 1991), increases in Ca 2ϩ during LTP may elevate cAMP.”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Xia et al., 1991
AC1 is expressed at relatively high levels in dentate granule cells of the hippocampus as well as cerebellar granule cells.
“AC1 is expressed at relatively high levels in dentate granule cells of the hippocampus as well as cerebellar granule cells (Xia et al., 1991).”
From Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation (1998) · cites this paper as Xia et al., 1991
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References 64 · Cited by 270
- Authors
- Xia, Z., Refsdal, C. D., Merchant, K. M., Dorsa, D. M., & Storm, D. R.
- Affiliations
- University of Washington (US)
- United States Department of Veterans Affairs (US)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 6
- Issue
- 3
- Pages
- 431-443
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2049356398
- Cited by
- 270
- References
- 64
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 12.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Merck Sharp and Dohme
- National Institute of Neurological Disorders and Stroke (R01NS020498, NS-20311, NS20498, R01NS020311)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- mRNA distribution, learning and memory, hippocampus, neocortex, olfactory system, pyramidal neurons, granule cells, neuroplasticity, rutabaga, rat brain
- MeSH terms
- Adenylyl Cyclases, Animals, Base Sequence, Brain, Calmodulin, Cerebral Cortex, DNA, Hippocampus, Learning, Male, Memory, Molecular Sequence Data, Nucleic Acid Hybridization, Olfactory Pathways, Oligonucleotides, Rats, Inbred Strains, RNA, Messenger, DNA Probes, Rats
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