Mechanosensitivity of NMDA receptors in cultured mouse central neurons
Abstract
Changes in osmotic and hydrostatic pressure were found to modulate NMDA responses of cultured embryonic mouse neurons recorded in various patch-clamp configurations. In nucleated patches, NMDA currents were potentiated by reductions in external osmolarity and were reduced in hyper-osmotic solutions. These changes, which were greater for low concentrations of NMDA, were not observed for responses to kainate, glycine, or GABA. They could be mimicked by directly changing the pipette pressure in nucleated, outside-out, inside-out, and cell-attached patches. Osmosensitivity of NMDA responses was also observed in the whole-cell mode, but only after prolonged dialysis. Mechanosensitivity of NMDA receptors could have an important role in neuronal regions experiencing changes in membrane tension, such as spines or growth cones.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One consequence of disrupting such membrane tension would be alteration of the mechanosensitive properties of NMDA receptors.
“One consequence of disrupting such membrane tension would be alteration of the mechanosensitive properties of NMDA receptors (Paoletti and Ascher, 1994).”
From Regulation of F-Actin Stability in Dendritic Spines by Glutamate Receptors and Calcineurin (1998) · cites this paper as Paoletti and Ascher, 1994
The citation lists haven’t been fetched yet
References 49 · Cited by 229
- Authors
- Paoletti, P., & Ascher, P.
- Affiliations
- École Normale Supérieure - PSL (FR)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1994-09
- Volume
- 13
- Issue
- 3
- Pages
- 645-655
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2019121351
- Cited by
- 229
- References
- 49
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 6 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 10
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Keywords
- NMDA receptor, mechanosensitivity, osmotic pressure, hydrostatic pressure, membrane tension, osmosensitivity, NMDA currents, kainic acid, glycine, GABA, patch-clamp recording, dendritic spines, growth cones
- MeSH terms
- Animals, Brain, Cells, Cultured, Electrophysiology, Hydrostatic Pressure, Mechanoreceptors, Neurons, Osmotic Pressure, Pressure, Receptors, N-Methyl-D-Aspartate, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
