The DOI matches its Crossref record; the references it cites are not checked yet.
The occurence of cancer in first admitted schizophrenic patients
Abstract
The incidence of cancer was studied in a cohort of all first admitted 9156 patients in Denmark with a diagnosis of schizophrenia in the period 1970-1987. The overall incidence of cancer was reduced particularly in the males. Adjustment for the smoking habits of psychiatric patients enhanced this risk reduction. Fewer than expected had been diagnosed with cancer prior to the first schizophrenia admission. This tendency was limited to the female patients. The reduced cancer incidence was particularly marked for genital cancers, in particular testicular cancer, and skin cancers including malignant melanoma. Breast cancer risk was not increased, thus not substantiating concerns that neuroleptics would increase breast cancer risk through the elevation of serum prolactin levels. Some available evidence in the literature supports the hypothesis of an antineoplastic effect of neuroleptics as an explanation for the low occurrence of cancer in schizophrenic patients. Further large sample studies including an extension of the follow-up of this cohort are needed to establish the reduced risk of cancer in schizophrenic patients as well as exploring the causes for this reduction.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies have demonstrated a decreased cancer risk in schizophrenia.
“Some studies have demonstrated a decreased cancer risk in schizophrenia (440-448).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [443]
Citations
The citation lists haven’t been fetched yet
References 51 · Cited by 142
Research works printed but not linked: 12
- Alström, 1942, Mortality in mental hospitals with especial regard to tuberculosis, Acta Psychiatr. Neurol.
- Arentsen, 1959, Patients in Danish psychiatric hospitals, Acta Jutlandica
- Büel, 1925, Maligne Tumoren bei Geisteskrankheiten, Alg. Zeitschr. Psychiatrie, 80, 312
- Du Pan, 1977, La mortalité par cancer chez les patients psychiatriques hospitalisés, Schweiz Med. Wschr., 107, 597
- Eicke, 1973, Günstige Verläufe bei Karzinompatienten unter zusätzlicher Behandlung mit Phenothiazinderivaten, Med. Klin., 68, 1015
- Eicke, 1975, Günstige Verläufe bei Karzinompatienten unter zusätzlicher Behandlung mit Phenothiazinderivaten, Med. Klin., 70, 186
- Hahnemann, 1931, Undersøgelse over kræftdødeligheden hos sindssyge (Investigation of cancer mortality in mentally ill patients), Ugeskr Laeger, 93, 1132
- Lührs, 1962, Über die Kombinations-behandlung mit entkoppelnden Substanzen bei malignen Tumoren, Krebsarzt, 17, 405
- Nielsen, 1988, Aendringer i danskernes rygevaner 1970–1987, Ugeskr. Laeger, 150, 2229
- Opsahl, 1933, Om krefthyppigheten blandt sinnssyke, Norsk Mag. Lægevidenskaben, 94, 771
- Rotkin, 1977, Studies on the epidemiology of cervix cancer: Expanded Sampling, Cancer Treatment Rep. 61, 173
- Ødegaard, 1951, Mortality in Norweigian mental hospitals 1926–1941, Acta Genet. Statist. Med., 2, 141
Metadata
- Authors
- Mortensen, P. B.
- Affiliations
- Aarhus University Hospital (DK)
- Corresponding author
- Mortensen, Preben Bo
- ORCID
- Mortensen, Preben Bo
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 1994-06
- Volume
- 12
- Issue
- 3
- Pages
- 185-194
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2052517254
- Cited by
- 142
- References
- 51
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 3 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 8 · 2014: 1 · 2013: 6 · 2012: 7
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
- Keywords
- schizophrenia, cancer incidence
- MeSH terms
- Denmark, Female, Humans, Male, Neoplasms, Registries, Risk Factors, Schizophrenia, Smoking, Antipsychotic Agents, Cohort Studies, Incidence, Sex Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
