Enhanced localization of liposomes with prolonged blood circulation time in infected lung tissue
Open accessAbstract
In an experimental model of unilateral pneumonia caused by Klebsiella pneumoniae in rats we investigated whether intravenous administration of liposomes with prolonged blood circulation time resulted in significant localization of liposomes in infected lung tissue. Liposomes (100 nm) composed of hydrogenated phosphatidylinositol:hydrogenated phosphatidylcholine:cholesterol (molar ratio, 1:10:5) radiolabeled with gallium-67-deferoxamine showed relatively long blood circulation time. The degree of localization of these long circulating liposomes in the infected left lung was significantly higher compared to that of localization of 110 nm egg phosphatidylglycerol:egg phosphatidylcholine:cholesterol (molar ratio, 1:10:5) liposomes which exhibited relatively short blood circulation time. At 16 h after administration of the long circulating liposomes (when 10% of the injected dose was still present in the bloodstream) localization of liposomes in the infected left lung was increased up to 10-fold compared to the left lung of uninfected rats, and appeared to be highly correlated with the intensity of the infection. In the uninfected right lung the localization of long circulating liposomes was not increased. The degree of localization of liposomes in the infected tissue is dependent on the residence time of liposomes in the blood compartment. The extent of localization of long circulating liposomes in infected tissue appeared to be dependent on the liposomal dose administered.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The degree of targeting is directly correlated with the severity of infection.
“some studies show that the degree of targeting is directly correlated with the severity of infection 51,52 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [52]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 16 · Cited by 89
Research works printed but not linked: 3
- 6 Juliano, R.L. (1989) in Drug carrier systems (Roerdink, F.H.D. and Kroon, A.M., eds.), pp. 249–279, John Wiley and Sons. Chichester.
- 8 Gabizon, A. and Papahadjopoulos, D. (1988) Proc. Natl. Acad. Sci. USA 85, 6949–6953.
- 19 Maruyama, K., Kennel, S.J. and Huang. L. (1990) Proc. Natl. Acad. Sci. USA 87, 5744–5748.
- Authors
- Bakker-Woudenberg, I. A. J. M., Lokerse, A. F., ten Kate, M. T., & Storm, G.
- Affiliations
- Erasmus University Rotterdam (NL)
- Utrecht University (NL)
- ORCID
- Storm, Gert
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 1992-04
- Volume
- 1138
- Issue
- 4
- Pages
- 318-326
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2160025282
- Cited by
- 89
- References
- 16
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 1 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Keywords
- liposomes, blood circulation time, pulmonary infection, pneumonia, Klebsiella pneumoniae, phosphatidylinositol, phosphatidylglycerol, radiolabeled liposomes, pulmonary drug delivery
- MeSH terms
- Animals, Disease Models, Animal, Female, Klebsiella Infections, Klebsiella pneumoniae, Liposomes, Lung, Pneumonia, Rats, Inbred Strains, Specific Pathogen-Free Organisms, Tissue Distribution, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
