The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells
Open accessAbstract
We studied the expression of 38 human homeobox genes belonging to the four HOX complex loci in embryonal carcinoma (EC) cells induced to differentiate by culturing them in a medium containing retinoic acid (RA). Genes located at the 3' end of each one of the four HOX loci are activated by RA in a sequential order colinear with their 3' to 5' arrangement in the cluster: 3' HOX genes respond early to the drug while upstream genes respond progressively later. Among the genes located at the 5' end of HOX loci RNase protection analysis reveals that one HOX3 gene and four HOX4 genes are weakly expressed in EC stem cells and downregulated upon treatment with 10(-5) M RA. While activation of early responding genes does not require continuous protein synthesis, the observed timing and polarity of gene activation is disrupted in the absence of protein synthesis.
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Citations
Cites
A human retinoic acid receptor which belongs to the family of nuclear receptors
Petkovich, M., Brand, N. J., Krust, A., & Chambon, P. (1987) · Nature · doi:10.1038/330444a0 · Cited by 2,214
Identification of a receptor for the morphogen retinoic acid
Giguere, V., Ong, E. S., Segui, P., & Evans, R. M. (1987) · Nature · doi:10.1038/330624a0 · Cited by 1,965
Cited by
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674
PARALOGOUS HOX GENES: Function and Regulation
Maconochie, M., Nonchev, S., Morrison, A., & Krumlauf, R. (1996) · Annual Review of Genetics · doi:10.1146/annurev.genet.30.1.529 · Cited by 220
Global gene expression patterns during neural differentiation of P19 embryonic carcinoma cells
Wei, Y., Harris, T., & Childs, G. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700409.x · Cited by 47
Metadata
- Authors
- Simeone, A., Acampora, D., Nigro, V., Faiella, A., D'Esposito, M., Stornaiuolo, A., Mavilio, F., & Boncinelli, E.
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1991-03
- Volume
- 33
- Issue
- 3
- Pages
- 215-227
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2038192335
- Cited by
- 293
- References
- 2
- FWCI
- 14.71
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. https://app.cochat.ai/papers/10.1016/0925-4773(91)90029-6
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- Simeone, A., Acampora, D., Nigro, V., Faiella, A., D'Esposito, M., Stornaiuolo, A., Mavilio, F., & Boncinelli, E. (1991). Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mechanisms of Development. https://doi.org/10.1016/0925-4773(91)90029-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
