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Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study
Open accessAbstract
There are both reproductive and nonreproductive behavioral differences between men and women. Brain regions involved in determining sexual behavior have been reported to differ between the sexes. Nonreproductive, cognitive functional differences between sexes might be reflected in higher-order cortical structural dimorphisms, which have not previously been studied. We hypothesized that cortical regions involved in verbal behavior (which is sexually dimorphic) would differ between sexes. Using magnetic resonance imaging, we assessed gray matter volumes in several cortical regions in 17 women and 43 men. Women had 23.2% (dorsolateral prefrontal cortex) and 12.8% (superior temporal gyrus) greater gray matter percentages (corrected for overall brain size and age) than men in a language-related cortical region, but not in a more visuospatially related cortical region. These data seem to establish sexually dimorphic structural differences in the cerebral cortex, consistent with prior cerebral blood flow reports.
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Citations
Cited by
Meltzer, H. Y. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.82 · Cited by 1,393
A meta-analysis of sex differences in human brain structure
Ruigrok, A. N. V., Salimi-Khorshidi, G., Lai, M.-C., Baron-Cohen, S., Lombardo, M. V., Tait, R. J., & Suckling, J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.004 · Cited by 1,192
Gur, R. C., Turetsky, B. I., Matsui, M., Yan, M., Bilker, W., Hughett, P., & Gur, R. E. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04065.1999 · Cited by 909
Sex differences in schizophrenia
Abel, K. M., Drake, R., & Goldstein, J. M. (2010) · International Review of Psychiatry · doi:10.3109/09540261.2010.515205 · Cited by 762
Abnormal asymmetry in language association cortex in autism
Herbert, M. R., Harris, G. J., Adrien, K. T., Ziegler, D. A., Makris, N., Kennedy, D. N., Lange, N. T., Chabris, C. F., Bakardjiev, A., Hodgson, J., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10349 · Cited by 314
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Metadata
- Authors
- Schlaepfer, T. E., Harris, G. J., Tien, A. Y., Peng, L., Lee, S., & Pearlson, G. D.
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 61
- Issue
- 3
- Pages
- 129-135
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W1993216966
- Cited by
- 227
- References
- 0
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schlaepfer, T. E., Harris, G. J., Tien, A. Y., Peng, L., Lee, S., & Pearlson, G. D. (1995). Structural differences in the cerebral cortex of healthy female and male subjects: a magnetic resonance imaging study. Psychiatry Research: Neuroimaging. https://doi.org/10.1016/0925-4927(95)02634-a
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