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Cited by 75Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

Dextran hydrogels for colon-specific drug delivery. V. Degradation in human intestinal incubation models

Simonsen, Lene, Hovgaard, Lars, Mortensen, Per Brøbech, Brøndsted, Helle·1995·European Journal of Pharmaceutical Sciences
DOI 10.1016/0928-0987(95)00023-6
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  • Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix.

    “Dextran is an exceptional carrier matrix for drug release in the colon as the enzyme dextranase breaks the 1,6-glycosidic bond of dextran and breaks down the hydrogel matrix (Hovgaard and Brøndsted, 1995; Simonsen et al., 1995; Chiu et al., 1999).”

    From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Simonsen et al., 1995

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References 41 · Cited by 75

Authors
Simonsen, L., Hovgaard, L., Mortensen, P. B., & Brøndsted, H.
Affiliations
Copenhagen University Hospital (DK)
Corresponding author
Hovgaard, Lars
Venue
European Journal of Pharmaceutical Sciences
Publisher
Elsevier BV
Published
1995-12
Volume
3
Issue
6
Pages
329-337
ISSN
0928-0987 (ISSN-L)
DOI
10.1016/0928-0987(95)00023-6
OpenAlex
W2062200635
Cited by
75
References
41
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 3
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
European Journal of Pharmaceutical Sciences (publishedVersion)
Funders
Sundhed og Sygdom, Det Frie Forskningsråd
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
dextran hydrogels, colon-targeted drug delivery, hydrogel degradation, colonic fermentation, short-chain fatty acids, crosslink density, degree of hydration, starch fermentation, cellulose, intestinal enzymes

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