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Protein prenylation: more than just glue?
Abstract
As with other lipid modifications of proteins, prenylation now appears to be critically important in the regulation of protein function. Recent research has led to an explosion of information concerning prenylation signals, prenyl transferase enzymes and the role of prenylation in protein-membrane interactions. Experiments have examined the role of prenylation in protein function and the results suggest that protein prenylation may be involved in facilitating proper subcellular localization, promoting protein-protein and protein-membrane interactions and regulating protein function.
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“The subcellular localization and function of Rho GTPases can be regulated by C-terminal prenylation at the CAAX motif.40–42”
From Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells (2008) · cites this paper as [40]
Citations
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Cited by
The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation
Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D., & Der, C. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.16.10608 · Cited by 177
Self-citationChae, H.-D., Lee, K. E., Williams, D. A., & Gu, Y. (2008) · Blood · doi:10.1182/blood-2007-06-093237 · Cited by 81
Metadata
- Authors
- Cox, A. D., & Der, C. J.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 4
- Issue
- 6
- Pages
- 1008-1016
- ISSN
- 0955-0674
- Cited by
- 169
- References
- 2
- Language
- en
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